Journal of Pediatric Perspectives

original article

Association between Transient Tachypnea of the Newborn and Serum Vitamin D Levels in Infants and Mothers in Natural Childbirth

Sareh Farshadfar; Fatemeh Hosseini; Ghazal Kahrizi; Arezoo Haseli; Azam Brimavandi

Volume 12, Issue 9 , September 2024, Pages 18988-18994

https://doi.org/10.22038/jpp.2024.82497.5481

Abstract

Background: Transient Tachypnea of the Newborn (TTN) is one of the most common causes of respiratory distress, shortly after birth, and is generally a benign, self-limited condition. ... Read More

original article

Clinical and Laboratory Findings in Children with Covid-19

Hosseinali Ghaffaripour; Sedigheh Hasani Ranjbar; Maryam Hassanzad; Mahsa MirZendehdel; Elham Sadati

Volume 12, Issue 9 , September 2024, Pages 18995-19007

https://doi.org/10.22038/jpp.2024.75151.5371

Abstract

Background: This study aimed to investigate the clinical characteristics of children diagnosed with COVID-19 in Dr. Masih Daneshvari Hospital from September 2021 to September 2022 to ... Read More

original article

Investigating the Diagnostic Value of Interleukin 33 Biomarker in the Diagnosis of Biliary Atresia in Infants with Cholestasis Admitted to Akbar Hospital in Mashhad

Forogh Ali Akbarniya Omran; Mohammadali Kiani; Hamid Ahanchian; Seyed Ali Jafari; Maryam Khalesi; hamidreza kianifar

Volume 12, Issue 9 , September 2024, Pages 19008-19021

https://doi.org/10.22038/jpp.2024.84856.5514

Abstract

Background: Neonatal cholestasis is one of the important liver diseases in children; and infants are more prone to it due to the immaturity of the liver. It appears due to several reasons ... Read More Background: Neonatal cholestasis is one of the important liver diseases in children; and infants are more prone to it due to the immaturity of the liver. It appears due to several reasons and its treatment is determined based on its cause. If the cause is not diagnosed in time and rapid treatment is not adopted, it will result in irreparable complications. Biliary atresia is the main cause of this disease and the most common symptom of the need for liver transplantation in children, which requires early diagnosis as a prognostic factor of the disease and its immediate differentiation from other causes of cholestasis. Considering the use of new diagnostic biomarkers, the present study was conducted with the aim of investigating the diagnostic value of serum interleukin 33 (IL-33) in infants with cholestasis and its relationship with clinical and laboratory data.Methods: This research is a cross-sectional study, conducted on infants referred to the gastroenterology clinic of Akbar Hospital in Mashhad during the years 2021 and 2022. According to the entry and exit criteria, cholestatic infants were included in the study in two groups with and without biliary atresia along with the control group (healthy infants). The basic information, clinical manifestations, and laboratory findings of infants were collected through a researcher-made checklist; and recorded in SPSS software version 24. Data description and analyses were done using descriptive indices, statistical tests, regression methods, and rock curve at a significance level of less than 0.05.Results: The participants included 78 infants with an average age of 2.80 ± 1.42 months, enrolled in three groups (26 cases each). The intervention groups consisted of patients with cholestasis with and without biliary atresia; and there was one group of healthy infants as the control group. The serum level of IL-33 biomarker was significantly higher in patients with biliary atresia than in patients without atresia (p=0.014); and in both groups, it was higher than that in the control group (p=0.001). The serum level of IL-33 had a significant positive correlation with laboratory indicators of AST, ALT and GGT (p<0.05). Interleukin-33 serum level at the cut-off point of 275 pg/ml can diagnose biliary atresia with a sensitivity of 84.6 and a specificity of 92.3%, so that the probability of biliary atresia in infants with IL-33 ≥ 275 is reported to be twice as often higher than that in infants with A serum levels lower than this value (p=0.011).Conclusion: The serum level of interleukin 33 was significantly higher in patients with biliary atresia than in patients without atresia as well as in healthy infants; and at the determined cut-off point, it had a favorable diagnostic value for identifying infants with biliary atresia.

original article

The Prevalence of Malnutrition in critically ill septic Pediatric: Findings from Akbar Children's Hospital in Mashhad

Ali Chamani; Mohsen Nematy; Faezeh Mashhadi; Mohammad Safarian; Majid Sezavar; Maryam Emadzadeh; Gholamreza Khademi; Fatemeh Roudi

Volume 12, Issue 9 , September 2024, Pages 19022-19031

https://doi.org/10.22038/jpp.2024.82331.5487

Abstract

Background: Sepsis is a potentially fatal condition resulting from an infection and is recognized as a critical global health concern. Among children, sepsis causes many deaths and ... Read More

original article

Injectable Acetaminophen Effectiveness in Closing Patent Ductus Arteriosus in Term Infants Hospitalized in the Neonatal Intensive Care Unit

Mohamad Mehdi Bagheri; Marjan Nikvarz; Reza Derakhshan; Zahra Daii Parizi; Fateme Mirzaie; Maryam Ahmadipour; Zahra Kamiab

Volume 12, Issue 9 , September 2024, Pages 19032-19039

https://doi.org/10.22038/jpp.2024.78636.5436

Abstract

Background: Patent ductus arteriosus is a short path of fetal blood circulation through the lungs that is necessary to maintain life inside the womb. Although this duct should be closed ... Read More Background: Patent ductus arteriosus is a short path of fetal blood circulation through the lungs that is necessary to maintain life inside the womb. Although this duct should be closed right after birth, in some cases, it remains open and may cause life threatening complications. The present study was conducted with the aim of investigating the effectiveness of injectable acetaminophen in closing patent ductus arteriosus in term infants.Methods: This study was conducted as a randomized, blinded clinical trial on 80 infants diagnosed with patent ductus arteriosus in the neonatal intensive care unit in Afzalipur Hospital, Kerman. The infants were randomly divided into control and intervention groups. The intervention group received injectable acetaminophen at a dose of 20 mg based on weight in the first hour and 10 mg based on weight every six hours for three days after receiving the initial dose. And the placebo group received 10% dextrose serum equal to acetaminophen amount with the same treatment intervals. Echocardiography was performed again in both groups after three days and the state of PDA closure was evaluated.Results: Gestational age averages in the intervention and control groups were 37.88 ± 0.13 weeks and 37.95 ± 0.15 weeks, respectively (P=0.738); and the birth weight averages were 2996 ± 83.41 grams and 64.09 ± 2982 grams, respectively (P=0.899). The male gender in the intervention group (57.5%) was higher than that in the control group (40%) (P=0.158). The most common cause of hospitalization of newborns in the intervention and control groups was TTN (Transient Tachypnea of the newborn) (75.0% and 67.5%, respectively) and NAS (Neonatal Abstinence Syndrome) (15.0% and 20.0%, respectively) (P=0.985). In the intervention group with injectable acetaminophen, 85.5% of infants had their PDA closed after receiving the first course of acetaminophen, while this rate was 0.65% in the control group (P=0.016).Conclusion: Based on the results of this study, injectable acetaminophen can effectively improve PDA disorder of term babies. While the effectiveness of routine drugs used in the treatment of this disorder decreases with increasing infants’ age, injectable acetaminophen showed its beneficial effects significantly.

systematic review

Complications and Outcome of Severe Acute Malnutrition in children under Five in Africa: A Systematic Review

Mariame Mohamed Ahamada; Goudja Gassara; Minrong Xiang; Jihua Chen

Volume 12, Issue 9 , September 2024, Pages 19040-19069

https://doi.org/10.22038/ijp.2024.71861.5273

Abstract

Background: This study aimed to examine the complications associated with Severe Acute Malnutrition (SAM), and the disease outcome in children under five years old in Africa.Methods: ... Read More

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Volume & Issue: Volume 12, Issue 9, September 2024, Pages 18988-19069

Association between Transient Tachypnea of the Newborn and Serum Vitamin D Levels in Infants and Mothers in Natural Childbirth

Abstract

Clinical and Laboratory Findings in Children with Covid-19

Abstract

Investigating the Diagnostic Value of Interleukin 33 Biomarker in the Diagnosis of Biliary Atresia in Infants with Cholestasis Admitted to Akbar Hospital in Mashhad

Abstract

The Prevalence of Malnutrition in critically ill septic Pediatric: Findings from Akbar Children's Hospital in Mashhad

Abstract

Injectable Acetaminophen Effectiveness in Closing Patent Ductus Arteriosus in Term Infants Hospitalized in the Neonatal Intensive Care Unit

Abstract

Complications and Outcome of Severe Acute Malnutrition in children under Five in Africa: A Systematic Review

Abstract