Document Type : original article
Authors
- mohamad mehdi - Bagheri 1
- marjan - nikvarz 2
- reza - derakhshan 1
- zahra daii parizi 3
- fateme - mirzaie 4
- maryam - ahmadipour 1
- zahra - kamiab 5
1 Associate professor of pediatric cardiology,department of pediatrics,school of medicine,kerman university of medical sciences,kerman,iran
2 Clinical Research Development Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran
3 Associate professor of pediatric Neonatology, department of pediatrics,school of medicine,kerman university of medical sciences,kerman,iran
4 Associate Professor, Department of Ob. & Gyn., Afzalipoor School of Medicine & Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
5 Associate professor of community medicine,department of family medicine,school of medicine,head of clinical research development unit,rafsanjan university of medical science,rafsanjan,iran.
Abstract
Background and purpose: Patent ductus arteriosus is a short path of fetal blood circulation through the lungs, that is necessary to maintain life inside the womb. Although this duct should be closed right after birth, in some cases, it remains open and may cause life threatening complications. The present study was conducted with the aim of investigating the effectiveness of injectable acetaminophen in closing patent ductus arteriosus in term infants.
Material and method: This study was conducted as a randomized, blinded clinical trial on 80 infants diagnosed with patent ductus arteriosus in the neonatal intensive care unit in Afzalipur Hospital, Kerman. The infants were randomly divided into control and intervention groups. The intervention group received injectable acetaminophen at a dose of 20 mg based on weight in the first hour and 10 mg based on weight every six hours for three days after the receiving the initial dose, and the placebo group, received 10% dextrose serum equal to acetaminophen amount with the same treatment intervals. Echocardiography was performed again in both groups after three days and the state of PDA closure was evaluated.: Based on the results of this study, injectable acetaminophen can effectively improve PDA disorder of term babies. Although the effectiveness of routine drugs used in the treatment of this disorder decreases with increasing infants’ age, injectable acetaminophen showed its beneficial effects significantly.
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