Insulinoma as the First Manifestation of MEN1: A Case of a 13-Year-Old Boy Presenting with Generalized Seizure and Hypoglycemia

Ahmadi, Pouria; Hasanabadi, Mohaamad Hossein

doi:10.22038/jpp.2026.92906.5619

Insulinoma as the First Manifestation of MEN1: A Case of a 13-Year-Old Boy Presenting with Generalized Seizure and Hypoglycemia

Document Type : case report

Authors

Pouria Ahmadi

Mohaamad Hossein Hasanabadi

Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.

10.22038/jpp.2026.92906.5619

Abstract

Hypoglycemia, a widespread metabolic complication in children, has harmful impacts on normal brain function and can progress to symptomatic seizures. This report describes a rare case of a 13-year-old male who presented with a generalized tonic-clonic seizure due to severe hypoglycemia. Further diagnostic workup with a PET/CT scan revealed an insulin-secreting pancreatic tumor and a diagnosis of Multiple Endocrine Neoplasia Type 1 (MEN1) was established based on genetic testing results. The patient underwent successful distal pancreatectomy, resulting in the normalization of blood glucose levels and resolution of symptoms. The primary aim of this report is to emphasize that seizures can be a key sign of insulinomas and MEN1 syndrome in children, despite the rarity of these conditions.

Keywords

Hypoglycemia

Insulinoma

MEN1

Pediatric

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