Journal of Pediatric Perspectives

Journal of Pediatric Perspectives

Vitamin B6 Impact on Pediatric Vomiting and Nausea in Gastroenteritis: A Case-Control Study in Southern Iran

Document Type : original article

Authors
Marjan Tariverdi 1
Mohammad Tamaddondar 2
Shokoh Makarian 3
Mohammad Satarzadeh 3
1 Assistant Professor of Pediatric Infectious Disease, Department of Pediatrics, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
2 Assistant Professor of Internal Diseases Training Department, Department of Nephrology, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
3 Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
10.22038/jpp.2025.76046.5387
Abstract
Background: Vomiting and nausea are common symptoms of Gastroenteritis (GE) in children, and high statistics in emergency department visits. Vitamin B6, which plays a significant role in preventing vomiting in pregnant women, is one of the options for controlling GE. This study examines the effect of pyridoxine (vitamin B6) in children with GE.
Method: The study population of this research was a case-control including all children aged 6 months to 12 years with mild to moderate dehydration who were admitted to the children's hospital in Bandar Abbas city between 2021 and 2022. The study included two groups: control and intervention. The intervention group consisted of patients aged 6 months to 14 years of both genders who received pyridoxine to manage nausea and vomiting based on thier weight.
Results: A total of 70 individuals were included in our study, of whom 48.57% were female and 51.43% were male. The percentage of dehydration in patients with gastroenteritis in the control group was 64.6±1.59%, while in the group treated with vitamin B6, it was 32.6±1.46%. There was no significant correlation between the percentage of dehydration in the control and vitamin B6-treated groups. Additionally, there was no significant correlation between the amount of fluid received and the mean length of hospital stay in both group.
Conclusion: Pyridoxine drug was not effective in treating vomiting caused by acute gastroenteritis in children compared to the control sample. Although vitamin B6 is effective in controlling inflammation, it was not able to reduce GE complications.
Keywords
Gastroenteritis
Pediatric
Pyridoxine
Vomiting
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Journal of Pediatric Perspectives
Volume 13, Issue 1
January 2025
Pages 19276-19283