The Role of Exosomes in the Pathogenesis of Intrauterine Growth Restriction (IUGR): Future Perspective

Document Type : review article

Authors

1 Shahid AkbarAbadi Clinical Research Development Unit (SHACRDU), School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

2 Department of Medical Genetics, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

3 Assistant Professor of Internal Medicine Department of Internal Medicine, School of Medicine Hazrat-e Rasool General Hospital Iran University of Medical Sciences.

4 Neonatal research center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

5 Resident of Obstetrics and Gynecology, Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Background: Exosomes are among the factors whose importance has been shown in many diseases today. Recently, it has been shown that exosomes play an important role in the pathogenesis of Intrauterine Growth Restriction (IUGR); however, few studies have been conducted in this regard.
Methods: The articles in this review study were retrieved from some databases including PubMed, Google scholar, and Scopus. All the included articles were in English, and those in other languages were excluded. Search keywords included IUGR, exosome, pathogenesis, Mechanism, Cell Signaling, Oxidative Stress, Inflammation, and Endothelial Dysfunction.
Results and conclusion: Studies have shown that exosomes contain factors, molecules and gene activators that affect molecular pathways regulation. These molecules play an important role in regulating inflammatory reactions, oxidative stress, and production of Reactive Oxygen Species (ROS). The activation of these pathways can aggravate the clinical symptoms of IUGR. In addition, exosomes can impress induction or inhibition of endothelial dysfunction, which leads to the development of IUGR. Hence, identifying upstream and downstream pathways helps design therapeutic strategies to treat patients.

Keywords

References

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Journal of Pediatric Perspectives
Volume 11, Issue 6
June 2023
Pages 17979-17989

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