Clinical and Socioeconomic Factors Associating with Opium Poisonings in Children and Adolescents

Document Type : original article

Authors

1 Children and Adolescents Health research center, Research Institute of cellular and Molecular Science in Infectious Diseases , Zahedan University of Medical Science's, Zahedan, Iran

2 Pregnancy Health Research Center, School of Nursing and Midwifery, Zahedan University of Medical Sciences, Zahedan- Iran

3 Pediatric resident, School of Medicine, Zahedan Univ Med Sci, Zahedan 9816743111, Iran

Abstract

Background: Use of opium and derivatives is one of the major health, psychosocial and socioeconomic problems and can lead to complications for societies. The present study aimed to assess clinical and socioeconomic factors associated with the poisonings by Opium and its Derivatives (O&D) in children and adolescents.
Methods: This retrospective study was carried out to review the recorded clinical information of children and adolescents admitted to the pediatric emergency department of the Ali Ibn Abi Talib Hospital due to acute poisoning by O&D during a seven-year period since 2014. Demo-economic information was taken from the patient’s guardians at the time of discharge. Collected data were analyzed by SPSS 20 considering 0.05 as the significant level.
Results: From among 227 poisoned children, 50.7% were female and 75.8%, 8.8% and 15.4% were in age groups of <8 year, 8-12 and 12-18 years, respectively. About 42.7% of the children poisoned by industrial substances, compared to the traditional substances. Respectively, 87.7%, 11% and 1.3% of the children were poisoned accidentally, intentionally, and due to family challenges or schooling problems. Variables of the children’s gender, age, and father’s age were associated with self-poisoning. The samples’ heart rate, blood pressure and seizure were affected by the type of narcotic.
Conclusion: Overall, the majority of poisoned children were girls and young. Those with very young and very old parents had more tendency to self-poison due to family challenges. Types of narcotic substances significantly correlated with irregular changes in the size of the pupil, heart rate, blood pressure and seizure.

Keywords

References

  1. Compton WM, Boyle M, Wargo E. Prescription opioid abuse: problems and responses. Preventive medicine. 2015 Nov 1; 80:5-9.
  2. Lal R, Deb KS, Kedia S. Substance use in women: Current status and future directions. Indian journal of psychiatry. 2015 Jul; 57(Suppl 2):S275.
  3. Amirabadizadeh A, Nezami H, Vaughn MG, Nakhaee S, Mehrpour O. Identifying risk factors for drug use in an Iranian treatment sample: A prediction approach using decision trees. Substance use & misuse. 2018 May 12; 53(6):1030-40.
  4. Soroosh D, Neamatshahi M, Zarmehri B, Nakhaee S, Mehrpour O. Drug-induced prolonged corrected QT interval in patients with methadone and opium overdose. Substance abuse treatment, prevention, and policy. 2019 Dec; 14(1):1-5.
  5. Eskandarieh S, Jafari F, Yazdani S, Hazrati N, Saberi-Zafarghandi MB. Compulsory maintenance treatment program amongst Iranian injection drug users and its side effects. International journal of high risk behaviors & addiction. 2014 Dec; 3(4).
  6. Pawłowicz U, Wasilewska A, Olański W, Stefanowicz M. Epidemiological study of acute poisoning in children: a 5-year retrospective study in the Pediatric University Hospital in Białystok, Poland. Emergency Medicine Journal. 2013 Sep 1; 30(9):712-6.
  7. Alizadeh A, Asoudeh MZ, Abdi F, Moshiri M, Mood MB, Etemad L. Epidemiological pattern of acute pediatric poisoning in Mashhad, Iran during 2011-2013. International Journal of High Risk Behaviors and Addiction. 2017; 6(2).
  8. Rathore S, Verma AK, Pandey A, Kumar S. Pediatric poisoning trend in Lucknow district, India. J Forensic Res. 2013; 4(1):179-80.
  9. Hasan Kara,Aysegul Bayir,Selim Degirmenci,Seyit Ali Kayis,Murat Akinci,Ahmet Ak, et al. Causes of poisoning in patients evaluated in a hospital emergency department in Konya, Turkey. JPMA 2014; 64: 1042-48.
  10. Titidezh V, Arefi M, Taghaddosinejad F, Behnoush B, Mahboobi M. Epidemiologic profile of deaths due to drug and chemical poisoning in patients referred to Baharloo Hospital of Tehran, 2011 to 2014. Journal of forensic and legal medicine. 2019 May 1; 64:31-3.
  11. Disfani HF, Kamandi M, Mousavi SM, Sadrzadeh SM, Farzaneh R, Doolabi N, Rahmani K. Risk factors contributing to the incidence and mortality of acute childhood poisoning in emergency department patients in Iran: a hospital-based case-control study. Epidemiology and health. 2019; 41.
  12. Finkelstein Y, Macdonald EM, Hollands S, Sivilotti ML, Hutson JR, Mamdani MM, Koren G, Juurlink DN, Canadian Drug Safety and Effectiveness Research Network (CDSERN. Risk of suicide following deliberate self-poisoning. JAMA psychiatry. 2015 Jun 1; 72(6):570-5.
  13. Senarathna L, Jayamanna SF, Kelly PJ, Buckley NA, Dibley MJ, Dawson AH. Changing epidemiologic patterns of deliberate self-poisoning in a rural district of Sri Lanka. BMC Public Health. 2012;12(1):593
  14. Martínez MA, Ballesteros S. Opium poisoning in modern times. An overview. Forensic science international. 2019 Sep 1; 302:109848.
  15. Khammarnia M, Peyvand M. The Reasons of Return to Drug Addiction and Suggested Solutions among the People Referring to Rehabilitation Centers: A Qualitative Study. JRUMS. 2018; 17 (6):523-538.
  16. Shokrzadeh M, Hajimohammadi A, Hoseinpoor R, Delaram A, Shayeste Y. An epidemiological survey of drug poisoning and a comparison with other poisoning cases admitted to a university hospital in Gorgan, Iran, 2008-2015. International journal of epidemiologic research. 2017; 4(2):94-103.
  17. Jabbehdari S, Farnaghi F, Shariatmadari SF, Jafari N, Mehregan FF, Karimzadeh P. Accidental children poisoning with methadone: an Iranian pediatric sectional study. Iranian journal of child neurology. 2013; 7(4):32.
  18. Ghaemi N, Alikhani S, Bagheri S, Sezavar M. A Cross sectional study of opioid poisoning in children at a tertiary center. Asia Pacific Journal of Medical Toxicology. 2016; 5(4):115-8.
  19. Khajeh A, Narouie B, Noori NM , Emamdadi A, Ghasemi Rad M,Kaykha M, et al. Patterns of Acute Poisoning in Childhood and Relative Factors in Zahedan, Southeast Iran. Shiraz E-Medical Journal. 2012 Jan; 13(3):19-27.
  20. Najafipour H, Beik A. The impact of opium consumption on blood glucose, serum lipids and blood pressure, and related mechanisms. Frontiers in physiology. 2016 Oct 13; 7:436.
  21. Yousefzadeh G, Shokoohi M, Najafipour H, Eslami M, Salehi F. Association between opium use and metabolic syndrome among an urban population in Southern Iran: Results of the Kerman Coronary Artery Disease Risk Factor Study (KERCADRS). ARYA atherosclerosis. 2015 Jan; 11(1):14.
  22. Zamani N, Sanaei-Zadeh H, Mostafazadeh B. Hallmarks of opium poisoning in infants and toddlers. Tropical doctor. 2010 Oct; 40(4):220-2.
  23. Farnaghi F, Jafari N, Mehregan FF. Methadone poisoning among children referred to Loghman-Hakim hospital in 2009. Pajoohandeh Journal. 2012 Feb 10; 16(6):299-303.
  24. Benedicta MO, Steinberg WJ, Van Loggerenberg CJ. The profile of deliberate self-poisoning cases presenting at the emergency department of Pelonomi Regional Hospital, Bloemfontein. South African Family Practice. 2019 Feb 1; 61(1):11-7.
  25. Sharif MR, Nouri S. Clinical signs and symptoms and laboratory findings of methadone poisoning in children. Iranian journal of pediatrics. 2015 Feb; 25(1).
  26. Ergun B, Cevik AA, Ilgin S, Atlı O, Saracoglu A, Acar N. Acute drug poisonings in Eskisehir, Turkey: A retrospective study. Turk J Pharm Sci. 2013 May 1; 10(2):303-12.
  27. Mansori K, Soori H, Farnaghi F, Khodakarim S. A case-control study on risk factors for unintentional childhood poisoning in Tehran. Medical journal of the Islamic Republic of Iran. 2016; 30:355.
  28. Norman RE, Byambaa M, De R, Butchart A, Scott J, Vos T. The long-term health consequences of child physical abuse, emotional abuse, and neglect: a systematic review and meta-analysis. PLoS medicine. 2012 Nov 27; 9(11):e1001349.
  29. Shahkolai FR, Bandehelahi K, Shahanjarini AK, Farhadian M. The factors related to mother's beliefs and behaviors concerning the prevention of poisoning among children under the age of five, using the Health Belief Model. Turkish journal of pediatrics. 2019 Sep 1; 61(5).
  30. Matteucci MJ, Hannum JE, Riffenburgh RH, Clark RF. Pediatric sex group differences in location of snakebite injuries requiring antivenom therapy. Journal of medical toxicology. 2007 Sep; 3(3):103-6.
  31. Soori H. Developmental of risk factors for unintentional childhood poisoning. Saudi medical journal. 2001; 22(3):227-30.
  32. Gibson, J. C., & Vulliamy, A. Accidental methadone poisoning in children: A call for Canadian research action. Child Abuse & Neglect, 2010; 34(8):553–554.
  33. Bilal A, Zafar F, Amna RS. Population attributable risk of unintentional childhood poisoning in Karachi Pakistan. Injury prevention. 2012 Oct 1; 18(Suppl 1):A114.
Journal of Pediatric Perspectives
Volume 10, Issue 5
May 2022
Pages 15957-15971

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