Glucose Oral Solution as A Pain-Relieving Agent In Infantile Colic: A Double Blinded Randomized Clinical Trial

Shahramian, Iraj; Moradi, Mandana; Afshari, Mahdi; Delaramnasab, Mojtaba; Sargazi, Alireza; Ebrahimi, Mahvash; Bazi, Ali

doi:10.22038/ijp.2017.27284.2353

Glucose Oral Solution as A Pain-Relieving Agent In Infantile Colic: A Double Blinded Randomized Clinical Trial

Authors

Iraj Shahramian ¹

Mandana Moradi ²

Mahdi Afshari ³

Mojtaba Delaramnasab ⁴

Alireza Sargazi ⁵

Mahvash Ebrahimi ⁶

Ali Bazi ⁴

¹ Associate Professor, Pediatric Ward, Zabol University of Medical Sciences, Zabol, Iran.

² Associate Professor, Clinical Pharmacy Department, Pharmacy School, Zabol University of Medical Sciences, Zabol, Iran.

³ Assistant Professor of Epidemiology, Zabol University of Medical Sciences, Zabol, Iran.

⁴ Clinical Research Development Unit, Amir-Al-Momenin Hospital, Zabol University of Medical Sciences, Zabol, Iran.

⁵ Zabol University of Medical Sciences

⁶ Student Research Committee, Zabol University of Medical Sciences, Zabol, Iran.

10.22038/ijp.2017.27284.2353

Abstract

Background
Infantile colic (IC) is a common painful disorder within early months of life. There is no definitive therapeutics for IC. In present study aimed to assess pain-relieving potential of glucose administration in infantile colic.
Materials and Methods
This was a double blinded randomized clinical trial performed during May 2015-June 2017 in pediatric ward of Amir-Al-Momenin Hospital, Zabol city, Iran. Overall, 72 infants were randomly assigned to either glucose or simethicone groups (36 infants per group). Treatments were continued for 28 days with either 25% or 30% glucose solution and 2.5 mg/kg simethicone. Outcomes were assessed at the end of the intervention (28 days). Statistical analysis was done in SPSS version 22.0.
Results
Males and females constituted 20 (55.5%), and 16 (45.5%) in glucose administrated, and 23 (63.8%) and 13 (36.2%, P=0.4) in simethicone group respectively. The mean age (days) was 19.1±3.8 and 20.2±4.9 for glucose and simethicone administrated groups, respectively (P=0.2). The crying times per day significantly reduced in both groups (mean reduction in crying times of 3.7±2.1, and 6.3±2.1 hours in glucose and simethicone groups, respectively). Moreover, 25% and 44.4% of infants in glucose and simethicone groups achieved ≥ 50% reduction in crying time, respectively (P=0.06). According to the glucose dose, infants who received 30% glucose solution significantly revealed higher ratio of ≥ 50% reduction in crying time (47.3%) than those received 25% glucose solution in which no cases fulfilled this outcome (P<0.0001).
Conclusion
Glucose may be a useful candidate to be considered as a pain-relieving agent in infantile colic.

Keywords

Abdominal Cramps

Glucose

Infantile colic

Simethicone