The Relationship between Blood Biomarkers Level and the Prognosis of Nephrotic Syndrome in the Children

Yousefichaijan, Parsa; Rezagholizamenjany, Masoud; Rafiei, Fatemeh; Taherahmadi, Hassan; Rafiei, Mohammad

doi:10.22038/ijp.2016.7302

The Relationship between Blood Biomarkers Level and the Prognosis of Nephrotic Syndrome in the Children

Authors

¹ Amir Kabir Hospital, Department of Pediatric Nephrology, Associate Professor of Pediatric Nephrology, School of Medicine, Arak University of Medical Sciences, Arak, Iran

² Medical Student, School of Medicine, Arak University of Medical Sciences, Arak, Iran.

³ Biostatistician, Departman of Biostatistics, Arak University of Medical Sciences, Arak, Iran.

⁴ Associate Professor of Pediatric Nephrology, Department of Pediatric Nephrology, Amir Kabir Hospital, Arak, Iran

10.22038/ijp.2016.7302

Abstract

Background
Nephrotic syndrome (NS) characterized by a large amounts of protein into urine and a set of indications that include: protein in urine, low blood protein levels, high cholesterol levels, high triglyceride levels, and swelling. Therefore, aim of this study was to investigate the relationship between prognosis of nephrotic syndrome and blood biomarkers level in children of Arak city, Iran.
Materials and Methods
This was a prospective study of case series patients which conducted on 100 chil‌dren with nephrotic syndrome referred to the pediatric clinic in Arak-Iran durring 2015 to 2016, to determine the resistance to steroids initially. All children had been taking Prednisolone and then, they were divided into four groups based on response to steroid. Also, blood biomarkers obtained from interviewing. Data were analyzed using SPSS-21.
Results
Results showed that children with steroids responded nephrotic syndrome rather than frequent relapse nephrotic syndrome, steroid resistance nephrotic syndrome and steroids dependent nephrotic syndrome patients had lower blood inflammatory and higher blood anti-inflammatory markers and there was a significant difference between these markers (P<0.05).
Conclusion
A number of inflammatory factors were lower than normal in responded group and number of anti-inflammatory factors was higher than normal in responded group. Therefore, in treatment of children, these inflammatory and anti-inflammatory factors should be controlled.

Keywords