Introduction:
A great percentage of AIDS infections occure in adolescence and youth.
since that,studing and finding the most efficient teaching methods in order to improve their information ( knowledge) and attitude also to create o positive one and to creat preventive measures in the young and adolescent,is of great significance and priority.
Materials and Methods: 7 school were picked randomy among different Mashhad educational districts.From these schools,650 students were  randomy  selected and divided into 4 groups:1-education with lecture, 2-education with guidebook, 3-education with lecture and guidebook,  4-without any education. Firstly ,  basic knowledge and attitude of students on AIDS were evaluated. Then their educational needs and curriculum were designed. Then 2 weeeks after cinducting the
 education,student's knowledge ( study groups ) and attitude were evaluated.
Results: Average Points for knowledge and attitude before education were 25.86 and 23.70 that were elevated to 27.68  and 25.27 after  aducation. There was no  statistical difference between average points of all 4 groups' knowledge and attitude before education. After education, average point of knowledge was 28.33+5.6 in  lecture group,28.19+6.26 in guidebook group, 29.77+4.49 in lecture and guidebook group and 26.90+4.95 in control group. After  education, average  points of attitude  was 25.77+3.7 in lecture group, 25.62+3.47 in guidebook group, 25.27+3.87 in lecture and guidebook  group  and 23.98+3.56 in  control group. Statistical analyses  showed that there is significant difference between points before and after education in the 3 study groups ( PConclusion:  To improve  student's  knowledge,  education by both lecture and guidebook, and to improve their attitude or to create a positive one, lecture method are preferred.