Document Type : original article
Authors
- Faezeh Mashhadi 1
- Mostafa Shahraki 1
- Fatemeh Sadat Hashemi Javaheri 1
- Mohammad Safarian 1
- Majid Sezavar 2
- Gholamreza Khademi 2
- Maryam Naseri 2
- Fatemeh Roudi 1
1 Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract
Background: Nutritional support in the Pediatric Intensive Care Unit (PICU) is critical for promoting recovery and reducing complications in critically ill children. Although guidelines exist, variability in Enteral Nutrition (EN) practices underscores the need for standardized protocols tailored to the unique needs of PICU patients. This study aimed to develop a standardized enteral feeding protocol for PICU patients, informed by current evidence and expert consensus, to improve feeding tolerance and clinical outcomes.
Methods: A two-phase study was conducted. Phase 1 involved a systematic review of global guidelines and evidence-based practices for EN in PICUs to identify key variables in EN delivery. In Phase 2, a multidisciplinary panel of PICU experts, including nutritionists and pediatric intensivists, used a structured focus group approach to develop a consensus on feeding initiation, volume advancement, prokinetic use, and complication management.
Results: The resulting protocol recommends initiating EN within 24 hours for hemodynamically stable patients, with gradual, weight-based volume advancement tailored to patient tolerance. Prokinetic agents (metoclopramide, domperidone, and erythromycin) were incorporated to improve feeding tolerance; and guidelines for managing potential complications, such as refeeding syndrome, gastrointestinal issues, and electrolyte imbalances, were established.
Conclusion: This protocol provides a comprehensive, evidence-based framework for EN in PICUs, offering structured guidance to support the nutritional needs of critically ill pediatric patients. While rigorous development ensures relevance and adaptability, further clinical evaluation is necessary to assess its impact across diverse PICU settings.
Keywords
- Ventura JC, Hauschild DB, Barbosa E, Bresolin NL, Kawai K, Mehta NM, et al. Undernutrition at PICU admission is predictor of 60-day mortality and PICU length of stay in critically ill children. Journal of the Academy of Nutrition and Dietetics. 2020 Feb 1;120(2):219-29.
- Briassoulis G, Ilia S, Meyer R. Enteral nutrition in PICUs: mission not impossible!. Pediatric Critical Care Medicine. 2016 Jan 1;17(1):85-7.
- Fell DM, Bitetto EA, Skillman HE. Timing of enteral nutrition and parenteral nutrition in the PICU. Nutrition in Clinical Practice. 2023 Oct;38:S174-212.
- Tume LN, Eveleens RD, Verbruggen SC, Harrison G, Latour JM, Valla FV. Barriers to delivery of enteral nutrition in pediatric intensive care: a world survey. Pediatric Critical Care Medicine. 2020 Sep 1;21(9):e661-71.
- Haseeb M, Goiporia MH, Siddiqui MS, Sangle AL, Quadri SF, Ravali RL. Challenges Encountered in the Provision of Enteral Nutrition in Pediatric Intensive Care Unit: An Observational Study. Cureus. 2023 Nov;15(11).
- Mustafa A. Challenges in Optimal Nutritional Care in Critically Ill Children in PICU-a Developing World Perspective (Doctoral dissertation, University of Nairobi).
- Tume LN, Valla FV, Joosten K, Jotterand Chaparro C, Latten L, Marino LV, et al. Nutritional support for children during critical illness: European Society of Pediatric and Neonatal Intensive Care (ESPNIC) metabolism, endocrine and nutrition section position statement and clinical recommendations. Intensive care medicine. 2020 Mar;46:411-25.
- Baǧci S, Keleş E, Girgin F, Yıldızdaş DR, Horoz ÖÖ, Yalındağ N, et al. Early initiated feeding versus early reached target enteral nutrition in critically ill children: An observational study in paediatric intensive care units in Turkey. Journal of paediatrics and child health. 2018 May;54(5):480-6.
- Dennis JL, Jordan J, Rice M, Lee AE. Enteral nutrition during extracorporeal membrane oxygenation in the neonatal and pediatric populations: a literature review. Pediatric Critical Care Medicine. 2023 Aug 1;24(8):e382-9.
- Cunningham CA, Gervais LB, Mazurak VC, Anand V, Garros D, Crick K, et al. Adherence to a nurse‐driven feeding protocol in a pediatric intensive care unit. Journal of Parenteral and Enteral nutrition. 2018 Feb;42(2):327-34.
- Veldscholte K, Cramer AB, de Jonge RC, Eveleens RD, Joosten KF, Verbruggen SC. Continuous versus intermittent nutrition in pediatric intensive care patients: protocol for a randomized controlled trial. JMIR research protocols. 2022 Jun 23;11(6):e36229.
- Kidd C, Hamzeh R, Hoskote A, Rodrigues W, O’Connor G. 44 Standardised enteral feeding protocols improve growth and clinical outcomes for infants on CICU.
- Stalmeijer RE, McNaughton N, Van Mook WN. Using focus groups in medical education research: AMEE Guide No. 91. Medical teacher. 2014 Nov 1;36(11):923-39.
- Mehta NM. Approach to enteral feeding in the PICU. Nutrition in Clinical Practice. 2009 Jun;24(3):377-87.
- Mehta NM, Skillman HE, Irving SY, Coss‐Bu JA, Vermilyea S, Farrington EA, et al. Guidelines for the provision and assessment of nutrition support therapy in the pediatric critically ill patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition. Journal of Parenteral and Enteral Nutrition. 2017 Jul;41(5):706-42.
- Prakash V, Parameswaran N, Biswal N. Early versus late enteral feeding in critically ill children: a randomized controlled trial. Intensive care medicine. 2016 Mar;42:481-2.
- Solana MJ, Manrique G, Slocker M, Fernández R, Gil R, Yun C, et al. Early vs late enteral nutrition in pediatric intensive care unit: Barriers, benefits, and complications. Nutrition in Clinical Practice. 2023 Apr;38(2):442-8.
- Schofield WN. Predicting basal metabolic rate, new standards and review of previous work. Human nutrition. Clinical nutrition. 1985 Jan 1;39:5-41.
- Taylor RM, Preedy VR, Baker AJ, Grimble G. Nutritional support in critically ill children. Clinical Nutrition. 2003 Aug 1;22(4):365-9.
- Khlevner J, Antino J, Panesar R, Chawla A. Establishing early enteral nutrition with the use of self‐advancing postpyloric feeding tube in critically ill children. Journal of Parenteral and Enteral Nutrition. 2012 Nov;36(6):750-2.
- Brown AM, Carpenter D, Keller G, Morgan S, Irving SY. Enteral nutrition in the PICU: current status and ongoing challenges. Journal of pediatric intensive care. 2015 Jun;4(02):111-20.
- Braudis NJ, Curley MA, Beaupre K, Thomas KC, Hardiman G, Laussen P, et al. Enteral feeding algorithm for infants with hypoplastic left heart syndrome poststage I palliation. Pediatric Critical Care Medicine. 2009 Jul 1;10(4):460-6.
- Geukers VG, de Neef M, Dijsselhof ME, Sauerwein HP, Bos AP. Effect of a nurse-driven feeding algorithm and the institution of a nutritional support team on energy and macronutrient intake in critically ill children. e-SPEN Journal. 2012 Feb 1;7(1):e35-40.
- Roudi F, Khademi G, Ranjbar G, Pouryazdanpanah M, Pahlavani N, Boskabady A, et al. The effects of implementation of a stepwise algorithmic protocol for nutrition care process in gastro-intestinal surgical children in Pediatric Intensive Care Unit (PICU). Clinical Nutrition ESPEN. 2021 Jun 1;43:250-8.
- Ketsuwan S, Tanpowpong P, Ruangwattanapaisarn N, Phaopant S, Suppalarkbunlue N, Kooanantkul C, et al. Intravenous metoclopramide to improve the success rate of blind bedside post-pyloric placement of feeding tube in critically ill children: A randomized, double-blind, placebo-controlled study. Frontiers in Pediatrics. 2021 Dec 22;9:739247.
- Camilleri M, Atieh J. New developments in prokinetic therapy for gastric motility disorders. Frontiers in pharmacology. 2021 Aug 24;12:711500.
- Weinstein RB, Fife D, Sloan S, Voss EA, Treem W. Prevalence of chronic metoclopramide use and associated diagnoses in the US pediatric population. Pediatric Drugs. 2015 Aug;17:331-7.
- Reddymasu SC, Soykan I, McCallum RW. Domperidone: review of pharmacology and clinical applications in gastroenterology. Official journal of the American College of Gastroenterology| ACG. 2007 Sep 1;102(9):2036-45.
- Szczupak M, Jankowska M, Jankowski B, Wierzchowska J, Kobak J, Szczupak P, et al. Prokinetic effect of erythromycin in the management of gastroparesis in critically ill patients—our experience and literature review. Frontiers in Medicine. 2024 Sep 9;11:1440992.
- Reignier J, Bensaid S, Perrin-Gachadoat D, Burdin M, Boiteau R, et al. Erythromycin and early enteral nutrition in mechanically ventilated patients. Critical care medicine. 2002 Jun 1;30(6):1237-41.
- Ericson JE, Arnold C, Cheeseman J, Cho J, Kaneko S, Clark RH, et al. Use and safety of erythromycin and metoclopramide in hospitalized infants. Journal of pediatric gastroenterology and nutrition. 2015 Sep 1;61(3):334-9.
- da Silva JS, Seres DS, Sabino K, Adams SC, Berdahl GJ, Citty SW, et al. ASPEN consensus recommendations for refeeding syndrome. Nutrition in Clinical Practice. 2020 Apr;35(2):178-95.
- Marino LV, Jotterand Chaparro C, Moullet C. Refeeding syndrome and other related issues in the paediatric intensive care unit. Pediatric medicine. 2020.
- Alkhawaja S, Martin C, Butler RJ, Gwadry‐Sridhar F. Post‐pyloric versus gastric tube feeding for preventing pneumonia and improving nutritional outcomes in critically ill adults. Cochrane Database of Systematic Reviews. 2015(8).
- Yasuda H, Kondo N, Yamamoto R, Asami S, Abe T, Tsujimoto H, et al. Monitoring of gastric residual volume during enteral nutrition. Cochrane Database of Systematic Reviews. 2021(9).
- McClave SA, Taylor BE, Martindale RG, Warren MM, Johnson DR, Braunschweig C, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (ASPEN). JPEN. Journal of parenteral and enteral nutrition. 2016 Feb 1;40(2):159-211.
- Singer P, Blaser AR, Berger MM, Calder PC, Casaer M, Hiesmayr M, et al. ESPEN practical and partially revised guideline: clinical nutrition in the intensive care unit. Clinical Nutrition. 2023 Sep 1;42(9):1671-89.
- Jenkins B, Calder PC, Marino LV. Gastric residual volume monitoring practices in UK intensive care units: a web-based survey. Journal of the Intensive Care Society. 2024 May;25(2):156-63.
- Feng L, Chen J, Xu Q. Is monitoring of gastric residual volume for critically ill patients with enteral nutrition necessary? A meta‐analysis and systematic review. International Journal of Nursing Practice. 2023 Dec;29(6):e13124.
- Reintam Blaser A, Deane AM, Preiser JC, Arabi YM, Jakob SM. Enteral feeding intolerance: updates in definitions and pathophysiology. Nutrition in clinical practice. 2021 Feb;36(1):40-9.
- Elke G, Felbinger TW, Heyland DK. Gastric residual volume in critically ill patients: a dead marker or still alive?. Nutrition in Clinical Practice. 2015 Feb;30(1):59-71.
- Jenkins B, Calder PC, Marino LV. A systematic review of the definitions and prevalence of feeding intolerance in critically ill adults. Clinical Nutrition ESPEN. 2022 Jun 1;49:92-102.
- Rosen R, Vandenplas Y, Singendonk M, Cabana M, DiLorenzo C, Gottrand F, et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Journal of pediatric gastroenterology and nutrition. 2018 Mar 1;66(3):516-54.
- Ojha S, Dorling J. Feed thickener for infants up to six months of age with gastro‐oesophageal reflux. Cochrane Database of Systematic Reviews. 2017(12).
- Horvath A, Dziechciarz P, Szajewska H. The effect of thickened-feed interventions on gastroesophageal reflux in infants: systematic review and meta-analysis of randomized, controlled trials. Pediatrics. 2008 Dec 1;122(6):e1268-77.
- Dupont C, Vandenplas Y. Different thickening complexes with pectin in infant anti‐regurgitation formula. Acta Paediatrica. 2020 Mar;109(3):471-80.
- Chouraqui JP, Brancato S, Delmas B, Hanh T. Effectiveness of a starch thickened infant formula with reduced lactose content, probiotics and prebiotics on quality of life and clinical outcome in infants with regurgitation and/or colic. Frontiers in Nutrition. 2023 May 25;10:1164722.
- Salvatore S, Klymenko V, Karpushenko Y, Durczak-Hilleman M, Loboda A, Petrashenko V, et al. Tolerance and Safety of an Anti-Regurgitation Formula Containing Locust Bean Gum, Pre-, and Postbiotics: A Multi-Country Multi-Center Prospective Randomized Controlled Study in Infants with Regurgitation. Nutrients. 2024 Mar 20;16(6):899.
- Bozzetti V, Tagliabue PE. Enteral nutrition for preterm infants: by bolus or continuous? An update. La Pediatria Medica e Chirurgica. 2017 Jun 28;39(2).
- Bittencourt AF, Martins JR, Logullo L, Shiroma G, Horie L, Ortolani MC, et al. Constipation is more frequent than diarrhea in patients fed exclusively by enteral nutrition: results of an observational study. Nutrition in clinical practice. 2012 Aug;27(4):533-9.
- Spapen H, Diltoer M, Van Malderen C, Opdenacker G, Suys E, Huyghens L. Soluble fiber reduces the incidence of diarrhea in septic patients receiving total enteral nutrition: a prospective, double-blind, randomized, and controlled trial. Clinical Nutrition. 2001 Aug 1;20(4):301-5.
- Lakananurak N, Nalinthassanai N, Suansawang W, Panarat P. Optimal hang time of enteral formula at standard room temperature and high temperature. World Journal of Clinical Cases. 2020 Oct 10;8(19):4410.
- Kadamani I, Itani M, Zahran E, Taha N. Incidence of aspiration and gastrointestinal complications in critically ill patients using continuous versus bolus infusion of enteral nutrition: a pseudo-randomised controlled trial. Australian Critical Care. 2014 Nov 1;27(4):188-93.