Document Type : original article

Authors

1 Heart Valve Disease Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

2 Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Abstract

Background: The Arterial Switch Operation (ASO) has been the preferred surgical method for Transposition of great arteries (TGA) since its introduction over 40 years ago. Although initial survival rates have improved significantly, long-term complications often require reoperation.
Methods: In this retrospective cohort study, medical records of 302 patients with TGA, who underwent ASO between 2004 and 2022, were reviewed. Data on demographic and morphological characteristics, surgical reports, and follow-up interventions were collected. Reoperation data, including surgical and catheter-based interventions, were analyzed.
Results: Thirty-seven reoperations were performed on 31 patients, with a reoperation rate of 10.26%. Open surgical interventions included Right Ventricle Outflow Tract Obstruction (RVOTO) relief (3.31%), neo-aortic root and valve surgery (0.66%), ascending aorta replacement (0.33%), VSD closure (0.33%), and pacemaker implantation (2.31%). Catheter-based interventions included balloon angioplasty (1.65%) and stent implantation (1.65%) for RVOTO, with additional procedures for aortic arch stenosis (0.66%) and coronary artery stenosis (0.33%). Residual shunts were treated in 0.99% of cases.
Conclusion: ASO has revolutionized the management of TGA, providing infants a chance at a normal, healthy life. As our understanding of congenital heart defects grows, ASO remains pivotal in enhancing patient outcomes. Despite the average time to reoperation being 4 years, regular follow-up is essential. Gradual complication development necessitates periodic monitoring to prevent escalation requiring surgical intervention.

Keywords

  1. Levin DL, Paul MH, Muster AJ, Newfeld EA, Waldman JD. d-Transposition of the great vessels in the neonate: a clinical diagnosis. Archives of Internal Medicine. 1977 Oct 1;137(10):1421-5.
  2. Warnes CA. Transposition of the great arteries. Circulation. 2006 Dec 12;114(24):2699-709.
  3. Rashkind WJ, Miller WW. Creation of an atrial septal defect without thoracotomy: a palliative approach to complete transposition of the great arteries. Jama. 1966 Jun 13;196(11):991-2.
  4. Mertens L, Vogt M, Marek J, Cohen MS. Transposition of the great arteries. Echocardiography in pediatric and congenital heart disease: From fetus to adult. 2016 Jan 21:446-65.
  5. Lalezari S, Bruggemans EF, Blom NA, Hazekamp MG. Thirty-year experience with the arterial switch operation. The Annals of thoracic surgery. 2011 Sep 1;92(3):973-9.
  6. Koubský K, Gebauer R, Tláskal T, Matějka T, Poruban R, Jičínská D, et al. Long‐term survival and freedom from coronary artery reintervention after arterial switch operation for transposition of the great arteries: a population‐based nationwide study. Journal of the American Heart Association. 2021 Jul 6;10(13):e020479.
  7. Vida VL, Zanotto L, Zanotto L, Stellin G, Group S, Padalino M, et al. Left-sided reoperations after arterial switch operation: a European multicenter study. The Annals of thoracic surgery. 2017 Sep 1;104(3):899-906.
  8. Tobler D, Williams WG, Jegatheeswaran A, Van Arsdell GS, McCrindle BW, Greutmann M, et al. Cardiac outcomes in young adult survivors of the arterial switch operation for transposition of the great arteries. Journal of the American College of Cardiology. 2010 Jun 29;56(1):58-64.
  9. van der Palen RL, Blom NA, Kuipers IM, Rammeloo LA, Jongbloed MR, Konings TC, et al. Long-term outcome after the arterial switch operation: 43 years of experience. European Journal of Cardio-Thoracic Surgery. 2021 May 1;59(5):968-77.
  10. Michalak KW, Moll JA, Sobczak-Budlewska K, Moll M, Dryżek P, Moszura T, et al. Reoperations and catheter interventions in patients with transposition of the great arteries after the arterial switch operation. European Journal of Cardio-Thoracic Surgery. 2017 Jan 1;51(1):34-42.
  11. Engele LJ, van der Palen RL, Joosen RS, Sieswerda GT, Schoof PH, van Melle JP, et al. Clinical course of TGA after arterial switch operation in the current era. JACC: Advances. 2024 Feb 1;3(2):100772.
  12. Broberg CS, van Dissel AC, Minnier J, Aboulhosn J, Kauling RM, Ginde S, et al. Long-term outcomes after atrial switch operation for transposition of the great arteries. Journal of the American College of Cardiology. 2022 Sep 6;80(10):951-63.
  13. Fricke TA, Buratto E, Weintraub RG, Bullock A, Wheaton G, Grigg L, et al. Long-term outcomes of the arterial switch operation. The Journal of thoracic and cardiovascular surgery. 2022 Jan 1;163(1):212-9.
  14. Raju V, Burkhart HM, Durham III LA, Eidem BW, Phillips SD, Li Z, et al. Reoperation after arterial switch: a 27-year experience. The Annals of thoracic surgery. 2013 Jun 1;95(6):2105-13.
  15. Jung JC, Kwak JG, Kim ER, Bang JH, Min J, Lim JH, et al. Reoperation for coronary artery stenosis after arterial switch operation. Interactive CardioVascular and Thoracic Surgery. 2018 Aug;27(2):169-76.
  16. Nguyen MT, Doan AV, Tran VQ, Mai DD, Nguyen UH, Nguyen TL. The arterial switch operation in the developing world: risk factors and current outcomes. The Annals of Thoracic Surgery. 2024 Mar 1;117(3):543-9.
  17. Menahem S, Ranjit MS, Stewart C, Brawn WJ, Mee RB, Wilkinson JL. Cardiac conduction abnormalities and rhythm changes after neonatal anatomical correction of transposition of the great arteries. Heart. 1992 Mar 1;67(3):246-9.
  18. Amoozgar H, Amirghofran AA, Salaminia S, Cheriki S, Borzoee M, Ajami G, et al. Evaluation of electrocardiographic changes after arterial switch operation. International cardiovascular research journal. 2014 Sep;8(3):99.
  19. Choi BS, Kwon BS, Kim GB, Bae EJ, Noh CI, Choi JY, et al. Long-term outcomes after an arterial switch operation for simple complete transposition of the great arteries. Korean Circulation Journal. 2010 Jan;40(1):23-30.