Journal of Pediatric Perspectives

Journal of Pediatric Perspectives

Magnitude of Neonatal Jaundice and Its Predictors among Neonates Admitted in NICUs in Ethiopia: A Facility-Based Cross-Sectional Study

Document Type : original article

Authors
Minale Bezie 1
Abenezer Melkie 1
Shimeles Biru 1
Mekonen Haile 1
Yismaw Yimam 2
1 Department of Midwifery, College of Health Science, Debre Tabor University, Ethiopia.
2 Department of Obstetrics and Gynecology, College of Health Sciences, Debre Tabor University.
10.22038/ijp.2024.62393.4772
Abstract
Background: Jaundice in neonates is one of the most common clinical problems. Neonatal jaundice is a yellowish discoloration of the white part of a newborn baby's eyes and skin caused by high bilirubin levels. Across the world, in each year around 1.1 million newborns develop neonatal jaundice and the majority of this occurs in sub-Saharan Africa and South Asia. There are limited studies on the magnitude and predictors of neonatal jaundice, in Ethiopia. So, this study aimed to assess the magnitude of neonatal jaundice and its predictors among neonates admitted in Neonatal Intensive Care Units (NICUs).
Methods: This Facility-based cross-sectional study was conducted, from December 2020 to April 2021, on 394 participants. Simple random sampling techniques were used to select hospitals; and samples were allocated proportionally to each hospital based on the number of women who gave birth. Methods of data collection used in this study were both interview and chart review. Chart review was applied for variables which are found on the patient charts. Interviews were used for variables which are not found on the patient chart. Data was entered in Epi-info version-7 software and exported to SPSS version 23 for editing, cleaning, and analysis. Bivariate and multivariate logistic regression analyses were used to identify predictors of neonatal jaundice. Variables with a p-value <0.2 in the bivariate analysis were entered into a multivariable model at a 95 % confidence level to identify predictors of neonatal jaundice while controlling for potential confounding factors. The significance of the association was determined using a P-value < 0.05.
Result: This study involved 394 mothers with their neonates. The response rate of this study was 100%; following. The magnitude of neonatal jaundice was 20.8% [95% CI: (6.32-27.64]. Being male neonate [AOR=1.52, 95 CI (1.32-8.54)], Prolonged labor [AOR=2.31; 95% CI (1.05-11.05)], primiparous mother [AOR=1.99; 95% CI (1.08-10.64)], neonatal sepsis [AOR=1.15; 95% CI (1.00-13.2)], and instrumental delivery [AOR=1.78; 95% CI (2.15-17.11)] were found to be the predictors of neonatal jaundice. It is recommended to practice essential obstetrical interventions such as following the laboring mothers in the active stage of labor with partograph to prevent prolonged labor, using aseptic technique during intrapartum and postpartum periods to prevent neonatal sepsis, and revising prerequisites and indications before the application of instrumental delivery.
Keywords
Ethiopia
Magnitude
Neonatal jaundice
Predictors
South Gondar
  1. Bhutani VK, Zipursky A, Blencowe H, Khanna R, Sgro M, Ebbesen F, et al. Neonatal hyperbilirubinemia and Rhesus disease of the newborn: incidence and impairment estimates for 2010 at regional and global levels. Pediatric research. 2013 Dec;74(1):86-100.
  2. Azar AT, Inbarani HH, Kumar SU, Own HS. Hybrid system based on bijective soft and neural network for Egyptian neonatal jaundice diagnosis. International Journal of Intelligent Engineering Informatics. 2016;4(1):71-90.
  3. Paridhi G, Nilesh D, Sumit A, Vinit W, Garg P. Study of Etiology of Neonatal Jaundice at tertiary care centre in Maharashtra. SJAMS ISSN. 2015;2320:6691.
  4. Bahl LA, Sharma RA, Sharma JA. Etiology of neonatal jaundice at Shimla. Indian pediatrics. 1994 Oct;31(10):1275-8.
  5. Lake EA, Abera GB, Azeze GA, Gebeyew NA, Demissie BW. Magnitude of neonatal jaundice and its associated factor in neonatal intensive care units of Mekelle city public hospitals, Northern Ethiopia. International journal of pediatrics. 2019;2019(1):1054943.
  6. Karayalcin G. Sickle cell anemia in the neonatal period. Southern Medical Journal. 1979 Apr 1;72(4):492-3.
  7. Austin CR. The mammalian fetus in vitro. Springer; 2013 Dec 14.
  8. Mesić I, Milas V, Međimurec M, Rimar Ž. Unconjugated pathological jaundice in newborns. Collegium antropologicum. 2014 Mar 31;38(1):173-8.
  9. Onyearugha CN, Onyire BN, Ugboma HA. Neonatal jaundice: Prevalence and associated factors as seen in Federal medical centre Abakaliki, Southeast Nigeria. J Clin Med Res. 2011 Mar 31;3(3):40-5.
  10. Scrafford CG, Mullany LC, Katz J, Khatry SK, LeClerq SC, Darmstadt GL, et al. Incidence of and risk factors for neonatal jaundice among newborns in southern N epal. Tropical Medicine & International Health. 2013 Nov;18(11):1317-28.
  11. Abdel-Aziz T, Azab N, Odah M, El-deen IM. Factors and assays identifying babies at riskto develop significant hyperbilirubinemia. International Journal of Innovative Research in Science, Engineering and Technology. 2014;3(2):9804-9.
  12. Worku B, Kassie A, Mekasha A, Tilahun B, Worku A. Predictors of early neonatal mortality at a neonatal intensive care unit of a specialized referral teaching hospital in Ethiopia. Ethiopian Journal of Health Development. 2012;26(3):200-7.
  13. Edmond KM, Zandoh C, Quigley MA, Amenga-Etego S, Owusu-Agyei S, Kirkwood BR. Delayed breastfeeding initiation increases risk of neonatal mortality. Pediatrics. 2006 Mar 1;117(3):e380-6.
  14. World Health Organization. Postpartum care of the mother and newborn: a practical guide: report of a technical working group. World Health Organization; 1998.
  15. ADAM NAI. Nurses’ knowledge and Practice regarding Management of Neonatal Jaundice under Phototherapy in Jafar Ibn Auf Pediatric Specialized Hospital, Khartoum State, Sudan: University of Gezira; 2013.
  16. Williams MS, Weiss EJ, Sabatine MS, Simon DI, Bahou WF, Becker LC, et al. Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development. Arteriosclerosis, thrombosis, and vascular biology. 2010 Dec 1;30(12):2372-84.
  17. Kleigman B. Jonson and Stanton. Nelson TextBook of Pediatrics. Elsevier, Philadelphia, Pa, USA; 2008.
  18. Omekwe DE, George MD, Kennis BT, Fakuma BN, Evdence CC, Destiny EF, et al. Survey and management outcome of neonatal jaundice from a developing tertiary health centre, Southern Nigeria. IOSR Journal of Dental and Medical Sciences. 2014;13(4):35-9.
  19. Olusanya BO, Akande AA, Emokpae A, Olowe SA. Infants with severe neonatal jaundice in Lagos, Nigeria: incidence, correlates and hearing screening outcomes. Tropical Medicine & International Health. 2009 Mar;14(3):301-10.
  20. Ali A, Tomar A. Etiological profile of neonatal hyperbilirubinaemia in the rural area of Rajasthan. Indian Journal of Basic and Applied Medical Research. 2015;4(2):223-32.
  21. Brits H, Adendorff J, Huisamen D, Beukes D, Botha K, Herbst H, et al. The prevalence of neonatal jaundice and risk factors in healthy term neonates at National District Hospital in Bloemfontein. African Journal of Primary Health Care and Family Medicine. 2018 May 3;10(1):1-6.
  22. Arad I, Fainmesser P, Birkenfeld A, Gulaiev B, Sadovsky E. Vacuum extraction and neonatal jaundice.
  23. Najib KS, Saki F, Hemmati F, Inaloo S. Incidence, risk factors and causes of severe neonatal hyperbilirubinemia in the South of iran (fars province). Iranian Red Crescent Medical Journal. 2013 Mar;15(3):260.
  24. Boskabadi H, Ashrafzadeh F, Azarkish F, Khakshour A. Complications of neonatal jaundice and the predisposing factors in‎ newborns. Journal of Babol University of Medical Sciences. 2015 Sep 10;17(9):7-13.
  25. Tavakolizadeh R, Izadi A, Seirafi G, Khedmat L, Mojtahedi SY. Maternal risk factors for neonatal jaundice: a hospital-based cross-sectional study in Tehran. European journal of translational myology. 2018 Jul 7;28(3).
Journal of Pediatric Perspectives
Volume 12, Issue 7
July 2024
Pages 14921-18930