A Comparative Study of the Effect of Vitamin D Administration with a Dose of 400 and a Dose of 800 Units on the Establishment of Normal Serum Levels in Premature Infants

Document Type : original article

Authors

1 Neonatal Research Center, Mofid Children's Hospital, Faculty of Medicine, Shahid Beheshti University of medical Sciences, Tehran, Iran.

2 Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

3 Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children’s Health, Shhid Beheshti University of Medical Sciences, Tehran, Iran.

4 Imam Ali hospital, zahedan University medical university, Zahedan, Iran.

Abstract

Background: This study was conducted to evaluate the impact of two different dosages of vitamin D (400 units versus 800 units) on achieving normal serum levels in premature infants.
Methods: In this randomized clinical trial, premature infants aged between 28 and 34 weeks, with a weight range of 1000 to 2000 grams, were randomly assigned to two groups: one receiving 400 units and the other 800 units of oral vitamin D drops daily.
Results: The results indicated that alterations in calcium and alkaline phosphatase (ALP) levels were not statistically significant. However, it was observed that the mean level of phosphorus within the first 24 hours and at the two-week mark was significantly lower in the group administered 800 units compared to those receiving 400 units (P < 0.05). Repeated measures ANOVA revealed that the overall changes in phosphorus levels were not statistically significant, suggesting that the observed differences at 24 hours and two weeks can be attributed to baseline variations between the groups. Additionally, it was found that vitamin D levels in infants receiving 800 units were significantly elevated at both the second and fourth weeks when compared to those receiving 400 units (P < 0.001).
Conclusion: The findings from this study demonstrate that infants receiving a high dosage of 800 units of vitamin D exhibited significantly higher vitamin D levels at both the second and fourth weeks compared to those receiving the standard dosage of 400 units.

Keywords

References

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Journal of Pediatric Perspectives
Volume 12, Issue 3
March 2024
Pages 18669-18680

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