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Epidemiology of Food Allergies in Children with Asthma in Gorgan, Northern Iran: a Cross-Sectional Population-Based Study

Document Type : original article

Authors

1 Pediatric Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran

2 Taleghani Hospital, Golestan University of Medical Sciences, Gorgan, Iran

3 Childern’s Medical Hospital, Tehran University of Medical Sciences, Tehran, Iran

4 Rafsanjan University of Medical Sciences, Rafsanjan, Iran

5 Immunology, Asthma & Allergy Research Institute, Imam Khomeini Hospital Complexes, Vali-e-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Background: Food allergy is a risk factor for asthma. In this study, we investigated the prevalence of food allergy in children with asthma.
Methods: This cross-sectional study included 200 children with asthma selected through available sampling; and was conducted in Taleghani Children’s Referral Hospital, Gorgan, Northern Iran, from 2014 to 2016. Greer® (USA) Skin Prick test (SPT) was used to recognize food allergens in all participating children. A questionnaire recorded children’s demographics. Statistical analysis was based on t-tests and chi-square using SPSS 16.
Results: The children's mean age was 10.29 ± 4.06 years. One hundred three children (51.5%) were females. The SPT of garlic, banana, kiwifruit, soybean, tomato, peanut, wheat, and walnut was significantly different between age groups (p<0.05). No statistically significant differences in food allergens were found between different genders, different age groups, and between the two groups of breastfeeding only and breastfeeding plus complimentary food. Allergy to curry powder, peanut, garlic, egg, and pepper was detected to be significantly higher than to other food allergens, (p<0.05). Atopia was detected in approximately all participants (99.5%).
Conclusion: Atopia seems to be an associated condition in asthmatic children. Allergy to curry powder, peanut, garlic, egg, and pepper, was significantly higher than other food allergies in children with asthma in Gorgan, Northern Iran.

Keywords

References
  1. Kliegman RM, Behrman RE, Jenson HB, Stanton BM. Nelson textbook of pediatrics e-book: Elsevier Health Sciences; 2007.
  2. Burks AW, Holgate ST, O'Hehir RE, Bacharier LB, Broide DH, Hershey GKK, et al. Middleton's allergy EBook: Principles and practice: Elsevier Health Sciences; 2019.
  3. Stern J, Pier J, Litonjua AA, editors. Asthma epidemiology and risk factors. Seminars in Immunopathology; 2020: Springer.
  4. Kuehn A, Codreanu‐Morel F, Lehners‐Weber C, Doyen V, Gomez‐André SA, Bienvenu F, Fischer J, Ballardini N, Hage MV, Perotin JM, Silcret-Grieu S, Chabane H, Hentges F, Ollert M, Hilger C, Morisset M. Cross‐reactivity to fish and chicken meat–a new clinical syndrome. Allergy. 2016; 71(12):1772-81.
  5. Renz H, Allen KJ, Sicherer SH, Sampson HA, Lack G, Beyer K, Oettgen HC. Food allergy. Nature reviews Disease primers. 2018; 4(1):1-20.
  6. Savage J, Johns CB. Food allergy: epidemiology and natural history. Immunology and Allergy Clinics. 2015; 35(1):45-59.
  7. Rona RJ, Keil T, Summers C, Gislason D, Zuidmeer L, Sodergren E, Sigurdardottir ST, Lindner T, Goldhahn K, Dahlstrom J, McBride D, Madsen C. The prevalence of food allergy: a meta-analysis. Journal of Allergy and Clinical Immunology. 2007; 120(3):638-46.
  8. Venter C, Arshad SH. Epidemiology of food allergy. Pediatric Clinics. 2011; 58(2):327-49.
  9. Liu AH, Jaramillo R, Sicherer SH, Wood RA, Bock SA, Burks AW, Massing M, Cohn RD, Zeldin DC. National prevalence and risk factors for food allergy and relationship to asthma: results from the National Health and Nutrition Examination Survey 2005-2006. Journal of Allergy and Clinical Immunology. 2010; 126(4):798-806. e14.
  10. Arabkhazaeli A, Vijverberg SJ, van Erp FC, Raaijmakers JA, van der Ent CK, van der Zee AHM. Characteristics and severity of asthma in children with and without atopic conditions: a cross-sectional study. BMC pediatrics. 2015; 15(1):172.
  11. Illi S, von Mutius E, Lau S, Nickel R, Niggemann B, Sommerfeld C, Wahn U; Multicenter Allergy Study Group. The pattern of atopic sensitization is associated with the development of asthma in childhood. Journal of allergy and clinical immunology. 2001; 108(5):709-14.
  12. Wang J, Visness CM, Sampson HA. Food allergen sensitization in inner-city children with asthma. Journal of allergy and clinical immunology. 2005; 115(5):1076-80.
  13. Sundquist BK, Jose J, Pauze D, Pauze D, Wang H, Järvinen KM, editors. Anaphylaxis risk factors for hospitalization and intensive care: a comparison between adults and children in an upstate New York emergency department. Allergy and asthma proceedings; 2019: OceanSide Publications.
  14. Litonjua AA. Dietary factors and the development of asthma. Immunology and allergy clinics of North America. 2008; 28(3):603-29.
  15. Werfel T. Food Allergy in adulthood. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz. 2016; 59(6):737-44.
  16. Iweala OI, Choudhary SK, Commins SP. Food allergy. Current gastroenterology reports. 2018; 20(5):17.
  17. Emons JA, van Wijk RG. Food allergy and asthma: Is there a link? Current Treatment Options in Allergy. 2018; 5(4):436-44.
  18. Horak F, Doberer D, Eber E, Horak E, Pohl W, Riedler J, Szépfalusi Z, Wantke F, Zacharasiewicz A, Studnicka M. Diagnosis and management of asthma–Statement on the 2015 GINA Guidelines. Wiener Klinische Wochenschrift. 2016; 128(15):541-54.
  19. Caffarelli C, Garrubba M, Greco C, Mastrorilli C, Povesi Dascola C. Asthma and food allergy in children: is there a connection or interaction? Frontiers in pediatrics. 2016; 4:34.
  20. Baral V, Hourihane JOB. Food allergy in children. Postgraduate medical journal. 2005; 81(961):693-701.
  21. Wheatley LM, Togias A. Allergic rhinitis. New England Journal of Medicine. 2015; 372(5):456-63.
  22. Odusote OA, Ubuane PO, Akinola IJ. Allergic comorbidities in childhood asthma in Lagos, Nigeria. Current Allergy & Clinical Immunology. 2020; 33(1):35-9.
  23. Sekerel B, Civelek E, Karabulut E, Yildirim S, Tuncer A, Adalioglu G. Are risk factors of childhood asthma predicting disease persistence in early adulthood different in the developing world? Allergy. 2006; 61(7):869-77.
  24. Nabavi M, Hoseinzadeh Y, Ghorbani R, Nabavi M. Prevalence of food allergy in asthmatic children under 18 years of age in Semnan-Iran in 2007-2008. Koomesh. 2010:162-9.
  25. Padilla J, Uceda M, Ziegler O, Lindo F, Herrera-Pérez E, Huicho L. Association between allergic rhinitis and asthma control in Peruvian school children: a cross-sectional study. BioMed research international. 2013; 2013.
  26. Nwaru B, Hickstein L, Panesar S, Roberts G, Muraro A, Sheikh A, EAACI Food Allergy and Anaphylaxis Guidelines Group. Prevalence of common food allergies in Europe: a systematic review and meta-analysis. Allergy. 2014; 69(8):992-1007.
  27. Cherian AA, Lakshmi Narasappa DS, Chandrasekaran V, Chinnakali P. Food allergy in children with asthma and its correlation with level of asthma control. Health Sci Rep. 2022; 6:5(1):e475.
  28. Minniti F, Comberiati P, Munblit D, L Piacentini G, Antoniazzi E, Zanoni L, L Boner A, G Peroni D. Breast-milk characteristics protecting against allergy. Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets-Immune, Endocrine & Metabolic Disorders). 2014; 14(1):9-15.
  29. León-Cava N, Lutter C, Ross J, Martin L. quantifying the benefits of breastfeeding: a summary of the evidence. Pan American Health Organization, Washington DC. 2002; 3:1-168.
  30. Matheson MC, Allen KJ, Tang ML. Understanding the evidence for and against the role of breastfeeding in allergy prevention. Clinical & Experimental Allergy. 2012; 42(6):827-51.
  31. Kramer MS, Matush L, Vasilovich I, Platt R, Bogdanovich N, Sevkovskaya Z, et al. Effect of prolonged and exclusive breastfeeding on risk of allergy and asthma: cluster randomized trial. Bmj. 2007; 335(7624):815.
  32. De Jong M, Scharp-Van Der Linden V, Aalberse R, Heymans H, Brunekreef B. The effect of brief neonatal exposure to cows' milk on atopic symptoms up to age 5. Archives of disease in childhood. 2002; 86(5):365-9.
  33. Kim JH. Role of breast-feeding in the development of atopic dermatitis in early childhood. Allergy, asthma & immunology research. 2017; 9(4):285-7.
  34. Løvik M, Namork E, Fæste C, Egaas E. The Norwegian national reporting system and register of severe allergic reactions to food. Norsk epidemiologi. 2004; 14(2).
  35. Afify SM, Pali-Schöll I. Adverse reactions to food: the female dominance–A secondary publication and update. World Allergy Organization Journal. 2017; 10(1):43.
  36. McGowan EC, Keet CA. Prevalence of self-reported food allergy in the National Health and Nutrition Examination Survey (NHANES) 2007-2010. Journal of Allergy and Clinical Immunology. 2013; 132(5):1216-9. e5.
  37. Schäfer T, Böhler E, Ruhdorfer S, Weigl L, Wessner D, Heinrich J, Filipiak B, Wichmann HE, Ring J. Epidemiology of food allergy/food intolerance in adults: associations with other manifestations of atopy. Allergy. 2001; 56(12):1172-9.
  38. Loh W, Tang ML. The epidemiology of food allergy in the global context. International journal of environmental research and public health. 2018; 15(9):2043.
  39. Liem JJ, Kozyrskyj AL, Huq SI, Becker AB. The risk of developing food allergy in premature or low-birth-weight children. Journal of allergy and clinical immunology. 2007; 119(5):1203-9.
  40. Control CfD, Prevention. National health interview survey 2014. National center for health statistics, health data interactive from www cdc gov/nchs/hdi htm. 2018.
  41. Osborne NJ, Koplin JJ, Martin PE, Gurrin LC, Lowe AJ, Matheson MC, Ponsonby AL, Wake M, Tang MLK, Dharmage SC, Allen KJ; HealthNuts Investigators. Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants. Journal of Allergy and Clinical Immunology. 2011; 127(3):668-76. e2.
  42. Peters RL, Koplin JJ, Gurrin LC, Dharmage SC, Wake M, Ponsonby A-L, Tang MLK, Lowe AJ, Matheson M, Dwyer T, Allen KJ; HealthNuts Study. The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: Health Nuts age 4-year follow-up. Journal of Allergy and Clinical Immunology. 2017; 140(1):145-53. e8.
Journal of Pediatric Perspectives
Volume 11, Issue 2
February 2023
Pages 17397-17404
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