Journal of Pediatric Perspectives

Journal of Pediatric Perspectives

The Association between Red Blood Cell Distribution Width and Metabolic Syndrome in Adolescent Girls

Document Type : original article

Authors
Mostafa Fazeli 1
Ali Reza Moslem 2
Zahra Meshkat 3
Ameneh Timar 4
Seyed-Amir Tabatabaeizadeh 5
Hamideh Ghazizadeh 6
Roshanak Ghaffarian Zirak 7
Meysam Moghbeli 6
Nadia Boroumand 8
Naghme jaberi 8
Mohammad Mohammadzadeh 9
Gordon A. Ferns 10
Hamid Reza Bahrami 4
Majid Ghayour-mobarhan 11
1 Department of medical genetic and molecular medicine, faculty of medicine, mashhad university of medical sciences
2 Department of Anesthesiology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
3 Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4 Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran
5 Clinical Nutrition Department, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
6 Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
7 Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
8 Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
9 Department of Physiology & Pharmacology, Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
10 Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK
11 Director of Department of New Sciences and Technology, Founding Member of Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences,Mashhad, Iran.
10.22038/ijp.2023.60826.4692
Abstract
Background: Metabolic syndrome (MetS) is characterized by metabolic and anthropometric abnormalities which are associated with an increased risk of cardiovascular disease (CVD). Red blood cell distribution width is a candidate biomarker for CVD.
Method: Nine hundred and eighty-eight girls who were between 12 to 18 years old were enrolled. Anthropometric parameters and blood pressure were measured, together with biochemical and hematological variables, using routine measures. International diabetes federation (IDF) criteria were used for the diagnosis of MetS.
Result: Some of the demographic parameters such as weight, neck circumference (NC), waist circumference (WC) and hip circumference (HP) were significantly different between the groups with and without MetS, as may be expected. Significantly higher values for red blood cell distribution width (RDW) were observed only in subjects with waist circumference (P= 0.017) and fasting blood glucose levels (P= 0.038). RDW measures were directly associated with MetS status (r=0.076 (P =0.043)), WC (r=0.097 (P =0.016)), and fasting blood glucose (FBG) (r= -0.085 (P =0.037)). It was found that the RDW had specificity and sensitivity for MetS-based IDF criteria 48.01 and 77.78, respectively. RDW related cure area (95% CI) for MetS was reported to be 0.588 (0.380- 0.796).
Conclusion: We found that an elevated RDW was associated with the presence of MetS and with some its components; but ROC analysis revealed that a weak specificity in spite of good sensitivity of RDW for MetS, along with a low AUC may make it unusable for the diagnostic prediction of MetS in this population.
Keywords
red blood cell distribution width
metabolic syndrome
cardiovascular disease
biomarker
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Journal of Pediatric Perspectives
Volume 11, Issue 2
February 2023
Pages 17416-17427