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Clinical Signs and Causes of Chronic Kidney Disease in Pediatrics

Document Type : original article

Authors

1 General Physician, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 Pediatric Nephrologist, Children & Adolescent Health Research Center, Resistant Tuberculosis Institute, School of Medicine, Zahedan Univ Med Sci, Zahedan 9816743111, Iran.

3 Demographer, Children and Adolescents Health research center, Research Institute of cellular and Molecular Science in Infectious Diseases , Zahedan University of Medical Science's, Zahedan, Iran

Abstract

Background: Chronic kidney disease (CKD) is a worldwide medical condition with increasing frequency that impairs the quality of life of children. This study aimed to assess the clinical signs and causes of CKD in children in Zahedan, Iran.
Methods: This cross-sectional study was run on 489 children up to 20 years with stages of 3 to 5 CKDs, in Zahedan during 2010-2019. Informed written consent was obtained from the patients’ parents. Data analysis was performed by SPSS 20 considering 0.05 as significant level.
Results: Amongst the clinical manifestations, edema (16.4%), (FTT) (13.5%), urinary symptoms (12.3%) and vomiting (11.5%) were more common and congenital structural anomalies (41.7%) were the most common cause of hospital admission. From among the studied children with CKD, 65.8% had stage 5, about 44.4% had conservative treatment and in total, 19.00% died. Most of the laboratory parameters were different in death and survival cases, for instance, Systolic and diastolic BP were higher in deaths when platelet blood was lower. Main causes of CKD (congenital structural anomalies, cystic/hereditary/congenital disease, glomerular diseases, Renal Tubular Disease, unknown origin and stone) had a significant association with gender (X2=13.42, p=0.02), treatments (X2=70.77, p<0.001), stage of CKD (X2=40.31, p<0.001) and survival (X2=11.59, p=0.041). Stages of CKD had a significant relation with treatment (X2=118.18, p<0.001), and survival (X2=26.5, p<0.001).
Conclusion: The causes of CKD were significantly associated with treatments, stage of CKD, and survival. Stages of CKD had significant associations with treatment and survival. Therefore, more attention to children with these signs is essential for early diagnosis and proper treatment.

Keywords

References
  1. Brück K, Stel VS, Fraser S, De Goeij MC, Caskey F, Abu-Hanna A, Jager KJ. Translational research in nephrology: chronic kidney disease prevention and public health. Clinical kidney journal. 2015 Dec 1; 8(6):647-55.
  2. Becherucci F, Roperto RM, Materassi M, Romagnani P. Chronic kidney disease in children. Clinical kidney journal. 2016 Aug 1; 9(4):583-91.
  3. Cattran DC, Feehally J, Cook HT, Liu ZH, Fervenza FC, Mezzano SA, Floege J, Nachman PH, Gipson DS, Praga M, Glassock RJ, Radhakrishnan J, Hodson EM, Rovin BH, Jha V, Troyanov S, Li PKT, Wetzels JFM. Kidney disease: improving global outcomes (KDIGO) glomerulonephritis work group. KDIGO clinical practice guideline for glomerulonephritis. Kidney International Supplements. 2012 Jun 1; 2(2):139-274.
  4. Warady BA, Chadha V. Chronic kidney disease in children: the global perspective. Pediatr Nephrol 2007; 22: 1999–2009.
  5. Saran R, Robinson B, Abbott KC, Agodoa LY, Albertus P, Ayanian J, et al., US renal data system 2016 annual data report: epidemiology of kidney disease in the United States. American journal of kidney diseases. 2017 Mar 1;69(3):A7-8.
  6. Coresh J, Astor BC, Greene T, Eknoyan G, Levey AS. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. American journal of kidney diseases. 2003 Jan 1; 41(1):1-2.
  7. Aghighi M, Mahdavi -Mazdeh M, Zamyadi M, Heidary Rouchi A, Rajolani H, Nourozi S. Changing epidemiology of end -stage renal disease in last 10 years in Iran. Iran J Kidney Dis. 2009; 3(4):192 -6.
  8. Gheissari A, Kelishadi R, Roomizadeh P, Abedini A, Haghjooy-Javanmard S, Abtahi SH, Mehdikhani B, Shafiei M. Chronic kidney disease stages 3-5 in Iranian children: Need for a school-based screening strategy: The CASPIAN-III study. International journal of preventive medicine. 2013 Jan; 4(1):95.
  9. Harambat J, Van Stralen KJ, Kim JJ, Tizard EJ. Epidemiology of chronic kidney disease in children. Pediatric nephrology. 2012 Mar; 27(3):363-73.
  10. Vivante A, Hildebrandt F. Exploring the genetic basis of early-onset chronic kidney disease. Nat Rev Nephrol 2016; 12: 133–146.
  11. Ding W, Cheung WW, Mak RH. Impact of obesity on kidney function and blood pressure in children. World J Nephrol 2015; 4: 223–229.
  12. Hooman N, Esfahani ST, Mohkam M, Derakhshan A, Gheissari A, Vazirian S,Mortazavi Ghane-Sherbaff F, Falak-Aflaki B, Otoukesh H, Madani A, Sharifian-Dorcheh M, Mahdavi A, Esmaeile M, Naseri M, Azhir A, Merikhi A, Mohseni P, Ataei N, Fallahzadeh MH, Basiratnia M, Hosseini-Al-Hashemi G, The outcome of Iranian children on continuous ambulatory peritoneal dialysis: the first report of Iranian National Registry. Arch Iran Med. 2009; 12(1):24 -8. 9.
  13. Ahmadzadeh A, Valavi E, Kamali M, Ahmadzadeh Azin. Chronic Kidney Disease in Southwestern Iranian Children. Iranian Journal of Pediatrics 2009. 19(2):147 -153.
  14. Rodig NM, McDermott KC, Schneider MF, Hotchkiss HM, Yadin O, Seikaly MG, Furth SL, Warady BA. Growth in children with chronic kidney disease: a report from the Chronic Kidney Disease in Children Study. Pediatric Nephrology. 2014 Oct; 29(10):1987-95.
  15. Gat-Yablonski G, Phillip M. Nutritionally-induced catch-up growth. Nutrients 2015; 7: 517–551.
  16. Soheilipour F, Hooman N, Ahmadvand P. Prevalence of Failure to Thrive in Iranian Children with Chronic Kidney Disease. Journal of Pediatric Nephrology. 2017; 5(3).
  17. Halle MP, Lapsap CT, Barla E, Fouda H, Djantio H, Moudze BK, Akazong CA, Priso EB. Epidemiology and outcomes of children with renal failure in the pediatric ward of a tertiary hospital in Cameroon. BMC pediatrics. 2017 Dec 1; 17(1):202.
  18. Derakhshan A, Al Hashemi GH, Fallahzadeh MH. Spectrum of in-patient renal diseases in children "a report from southern part Islamic Republic of Iran". Saudi Journal of Kidney Diseases and Transplantation. 2004; 15(1):12.
  19. Ocheke IE, Okolo SN, Bode-Thomas F, Agaba EI. Pattern of childhood renal diseases in Jos, Nigeria: a preliminary report. Journal of Medicine in the Tropics. 2010; 12(2).
  20. Ali E-TM, Rahman AH, Karrar ZA. Pattern and outcome of renal diseases in hospitalized children in Khartoum state. Sudan Sudanese Journal of Paediatrics. 2012; 12(2):52.
  21. Elzouki AY, Amin F, Jaiswal OP. Prevalence and pattern of renal disease in eastern Libya. Arch Dis Child 1983; 58:106-9.
  22. Yadav SP, Shah GS, Mishra OP, Baral N. Pattern of renal diseases in children: A developing country experience. Saudi Journal of Kidney Diseases and Transplantation. 2016 Mar 1; 27(2):371.
  23. Ahmadzadeh A, Valavi E, ZANGENEH KM, Ahmadzadeh A. Chronic kidney disease in Southwestern Iran J Pediatr. 2009; 19 (2); 147-153.
  24. Olowu WA, Niang A, Osafo C, Ashuntantang G, Arogundade FA, Porter J, Naicker S, Luyckx VA. Outcomes of acute kidney injury in children and adults in sub-Saharan Africa: a systematic review. Lancet Glob Health. 2016; 4(4):e242–e50.
  25. Chou HH, Lin CY, Chiou YH, Tain YL, Wang YF, Wang HH, Chiou YY. Clinical characteristics and prevalence of complications of chronic kidney disease in children: The Taiwan Pediatric Renal Collaborative study. Pediatric Nephrology. 2016 Jul 1; 31(7):1113-2.
  26. Van der Heijden BJ, van Dijk PC, Verrier-Jones K, Jager KJ, Briggs JD. Renal replacement therapy in children: data from 12 registries in Europe. Pediatr Nephrol. 2004; 19(2):213–21.
  27. Kara MA, Kilic BD, Çöl N, Özçelik AA, Büyükçelik M, Balat A. Kidney disease profile of Syrian refugee children. Iranian Journal of Kidney Diseases. 2017 Mar 1; 11(2):109.
  28. Ataei N, Hosseini M, Baikpour M, Ataei F, Bloori Jirandeh H, Bazargani B, Yousefifard M, Abbasi A. Etiology and outcome of chronic kidney disease in iranian children. International Journal of Pediatrics. 2016; 4(7):2105-12.
  29. Huong NTQ, Long TD, Bouissou F, Liem NT, Truong DM, Nga DK, Chien TT, Bascands JL, Chronic kidney disease in children: the National Paediatric Hospital experience in Hanoi, Vietnam. Nephrology. 2009 Dec; 14(8):722-7.
  30. Odetunde OI, Okafor HU, Uwaezuoke SN, Ezeonwu BU, Adiele KD, Ukoha OM. Chronic kidney disease in children as seen in a tertiary hospital in Enugu, South-East, Nigeria. Nigerian journal of clinical practice. 2014 Mar 27; 17(2):196-200.
  31. Liyanage T, Ninomiya T, Jha V, Neal B, Patrice HM, Okpechi I, Zhao MH, Lv J, Garg AX, Knight J, Rodgers A, Gallagher M, Kotwal S, Cass A, Perkovic V. Worldwide access to treatment for end-stage kidney disease: a systematic review. Lancet. 2015; 385(9981):1975–82.
  32. Obiagwu PN, Abdu A. Peritoneal dialysis vs. haemodialysis in the management of paediatric acute kidney injury in Kano, Nigeria: a cost analysis. Tropical Med Int Health. 2015; 20(1):2–7.
  33. Sadeghi-Bojd S, Noori NM, Mohammadi M, Teimouri A. Clinical characteristics and mortality risk prediction in children with acute kidney injury. Nigerian medical journal: journal of the Nigeria Medical Association. 2015; 56(5):327.
  34. Sadeghi-Bojd S, Noori NM, Damani E, Teimouri A. Electrolyte disturbances in PICU: A cross sectional study. Nephro-Urology Monthly. 2019; 11(2).
Journal of Pediatric Perspectives
Volume 10, Issue 8
August 2022
Pages 16434-16448
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