Comparing the Effectiveness of Curosurf and Beraksurf in the Treatment of Respiratory Distress in Premature Infants

Nourollahi, Sajad; Hashemi, Freshteh; Shafiei, Elham; Pirinegad, Omid

doi:10.22038/ijp.2022.62180.4764

Comparing the Effectiveness of Curosurf and Beraksurf in the Treatment of Respiratory Distress in Premature Infants

Document Type : original article

Authors

Sajad Nourollahi ¹

Freshteh Hashemi ²

Elham Shafiei ³

Omid Pirinegad ²

¹ Assistant Professor of Neonatal-Perinatal Medicine,Department of Pediatrics, School of Medicine Ayatollah Taleghani Hospital, Ilam University of Medical sciences, Ilam, Iran.

² Department of Pediatrics, School of Medicine Ayatollah Taleghani Hospital Ilam University of Medical sciences,Ilam.IRAN

³ Non-Communicable Diseases Research Center, Ilam University of Medical Sciences,Ilam,Iran.

10.22038/ijp.2022.62180.4764

Abstract

Background: Research evidence has approved the effectiveness of surfactant prescription for respiratory distress syndrome (RDS). However, previous studies have not reported the priority of curosurf and Beraksurf. The present study aimed to compare the effectiveness of Iranian surfactant (beraksurf) and Italian surfactant (curosurf) in the treatment of pulmonary distress.
Methods: This clinical trial was performed on 80 premature infants with respiratory distress in NICU of Taleghani Hospital in Ilam, all of whom were treated with surfactant.
Results: There was no significant difference regarding the duration of needs for ventilation and/or oxygen, duration of hospitalization, pulmonary hemorrhage, bronchopulmonary dysplasia, intraventricular hemorrhage, patent ductus arteriosus (PDA) and pneumothorax between the groups (p>0.05).
Conclusion: Beraksurf seems to be as effective as curosurf in premature neonates with RDS, but is less expensive than it.

Keywords

Infants

Premature

Surfactant

Beraksurf

Curosurf

Raimondi F, Migliaro F, Corsini I, Meneghin F, Dolce P, Pierri L, Perri A, Aversa S, Nobile S, Lama S, Varano S, Savoia M, Gatto S, Leonardi V, Capasso L, Carnielli VP, Mosca F, Dani C, Vento G, Lista G. Lung ultrasound score progress in neonatal respiratory distress syndrome. Pediatrics. 2021; 147(4).
Fitri N, Efendi D. Factors that impact the accuracy with which nurses place preterm infants with respiratory distress syndrome in the prone position. La Pediatria Medica e Chirurgica. 2021; 43(s1).
Course C, Chakraborty M. Management of respiratory distress syndrome in preterm infants in wales: a full audit cycle of a quality improvement project. Scientific reports. 2020; 10(1):1-7.
Gahlawat V, Chellani H, Saini I, Gupta S. Predictors of mortality in premature babies with respiratory distress syndrome treated by early rescue surfactant therapy. Journal of Neonatal-Perinatal Medicine. 2021(Preprint):1-6.
Kothe TB, Sadiq FH, Burleyson N, Williams HL, Anderson C, Hillman NH. Surfactant and budesonide for respiratory distress syndrome: an observational study. Pediatric research. 2020; 87(5):940-5.
Monfredini C, Cavallin F, Villani PE, Paterlini G, Allais B, Trevisanuto D. Meconium Aspiration Syndrome: A Narrative Review. Children. 2021; 8(3):230.
Singh R, Javed A, Sharma R. Assessment of outcome of acute respiratory distress syndrome in premature babies in mothers on antenatal corticosteroids. International Journal of Health and Clinical Research. 2021; 4(9):39-41.
De Luca D. Respiratory distress syndrome in preterm neonates in the era of precision medicine: a modern critical care-based approach. Pediatrics & Neonatology. 2020.
Brasher M, Raffay TM, Cunningham MD, Abu Jawdeh EG. Aerosolized Surfactant for Preterm Infants with Respiratory Distress Syndrome. Children. 2021; 8(6):493.
Dhar DK, Paul D. Surfactant Replacement Therapy: An Overview.
Hentschel R, Bohlin K, van Kaam A, Fuchs H, Danhaive O. Surfactant replacement therapy: from biological basis to current clinical practice. Pediatric research. 2020; 88(2):176-83.
Jahan R, Bodratti AM, Tsianou M, Alexandridis P. Biosurfactants, natural alternatives to synthetic surfactants: physicochemical properties and applications. Advances in colloid and interface science. 2020; 275:102061.
Saeedi R, Hamedi A, Javadi A, Gholami Robatsangi M, Dinparvar SK. Comparison of side effects of survanta and curosurf in decreasing mortality due to respiratory distress syndrome (RDS) in premature infants admitted in NICU of Ghaem Hospital On 2006-2008. Iranian Journal of Neonatology IJN. 2013; 4(3):7-12.
Baroutis G, Kaleyias J, Liarou T, Papathoma E, Hatzistamatiou Z, Costalos C. Comparison of three treatment regimens of natural surfactant preparations in neonatal respiratory distress syndrome. European journal of pediatrics. 2003; 162(7):476-80.
Ramanathan R, Rasmussen MR, Gerstmann DR, Finer N, Sekar K, Group nTNAS. A randomized, multicenter masked comparison trial of poractant alfa (Curosurf) versus beractant (Survanta) in the treatment of respiratory distress syndrome in preterm infants. American journal of perinatology. 2004; 21(03):109-19.
Najafian B, Karimi-Sari H, Khosravi MH, Nikjoo N, Amin S, Shohrati M. Comparison of efficacy and safety of two available natural surfactants in Iran, Curosurf and Survanta in treatment of neonatal respiratory distress syndrome: a randomized clinical trial. Contemporary clinical trials communications. 2016; 3:55-9.