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EVALUATION OF THE ROLE OF ANTIBIOTIC USE IN THE DEVELOPMENT OF COW'S MILK PROTEIN ALLERGY WITHIN THE FIRST YEAR OF LIFE AMONG PATIENTS TREATED IN THE NEONATAL INTENSIVE CARE UNIT

Document Type : original article

Authors

1 Karabük University Faculty of Medicine, Department of Pediatrics, Neonatal Intensive Care Unit, 78100, Kılavuzlar/Karabuk. TURKEY

2 Karabuk University Medicine Faculty

3 Karabük University Faculty of Medicine, Department of Family medicine, 78100, Kılavuzlar/Karabuk. TURKEY

4 Ankara City Hospital Neonatal Intensive Care drturanderme@gmail.com

Abstract

Introduction: It has been reported that the incidence of cow's milk protein allergy (CMPA) has increased in recent years, especially among infants in the first year of life. It is thought that the use of antibiotics may trigger the development of CMPA by causing intestinal dysbiosis and altering immune response, and thus, it may be a factor responsible for the supposed increase. The relationship between antibiotic use and the development of CMPA has been evaluated in very few studies in the literature. Our aim is to evaluate whether CMPA development is associated with antibiotic use during pregnancy or neonatal period.

Method: The development of CMPA within the first year of life among infants hospitalized and followed up in the Neonatal Intensive Care Unit (NICU) of Karabuk University Faculty of Medicine, Training and Research Hospital, between January 1, 2017 and October 30, 2020, was evaluated.

Results: During the study period, 1120 babies were followed up in our NICU. When the data of 975 babies who met the inclusion criteria were evaluated, it was found that the use of antenatal and conclusion postnatal antibiotics did not increase the development of CMPA.

Conclusion : The data of our study contradicts the two study of which previously associated maternal and infant antibiotic use with the development of CMPA.This contradiction suggests that the aetiology of CMPA is multifactorial and more studies are needed to elucidate the antibiotic-CMPA relationship.

Keywords

References
  1. Høst A. Frequency of cow's milk allergy in childhood. Ann Allergy Asthma Immunol. 2002 Dec; 89(6 Suppl 1):33-7.

2 .Metsälä J, Lundqvist A, Virta LJ, Kaila M, Gissler M, Virtanen SM. Mother's and offspring's use of antibiotics and infant allergy to cow's milk. Epidemiology. 2013 Mar; 24(2):303-9.

  1. Tsabouri S, Priftis KN, Chaliasos N, et al. Modulation of gutmicrobiota downregulates the development of food allergy ininfancy. Allergol Immunopathol (Madr). 2014; 42:69-77.9.
  2. Kuo CH, Kuo HF, Huang CH, et al. Early life exposure to antibi-otics and the risk of childhood allergic diseases: An update fromthe perspective of the hygiene hypothesis. J Microbiol ImmunolInfect. 2013; 46:320-9
  3. Marrs T, Bruce KD, Logan K, Rivett DW, Perkin MR, Lack G, Flohr C. Is there an association between microbial exposure and food allergy? A systematic review. Pediatr Allergy Immunol. 2013 Jun; 24(4):311-320.e8.
  4. Celedón JC, Litonjua AA, Ryan L, Weiss ST, Gold DR. Lack of association between antibiotic uses in the first year of life and asthma, allergic rhinitis, or eczema at age 5 years. Am J Respir Crit Care Med. 2002 Jul 1; 166(1):72-5.
  5. Celedón JC, Fuhlbrigge A, Rifas-Shiman S, Weiss ST, Finkelstein JA. Antibiotic use in the first year of life and asthma in early childhood. Clin Exp Allergy. 2004 Jul; 34(7):1011
  6. Kusel MM, de Klerk N, Holt PG, Sly PD. Antibiotic use in the first year of life and risk of atopic disease in early childhood. Clin Exp Allergy. 2008 Dec; 38(12):1921-8.
  7. Verhulst SL, Vael C, Beunckens C, Nelen V, Goossens H, Desager K. A longitudinal analysis on the association between antibiotic use, intestinal microflora, and wheezing during the first year of life. J Asthma. 2008 Nov; 45(9):828-32

10.Wickens K, Ingham T, Epton M, Pattemore P, Town I, Fishwick D, Crane J; New Zealand Asthma and Allergy Cohort Study Group. The association of early life exposure to antibiotics and the development of asthma, eczema and atopy in a birth cohort: confounding or causality? Clin Exp Allergy. 2008 Aug; 38(8):1318-24.

  1. Eggesbø M, Botten G, Stigum H, Nafstad P, Magnus P. Is delivery by cesarean section a risk factor for food allergy? J Allergy Clin Immunol.2003; 112:420–426.
  2. Toro Monjaraz EM, Ramírez Mayans JA, Cervantes Bustamante R, Gómez Morales E, Molina Rosales A, Montijo Barrios E, Zárate Mondragón F, Cadena León J, Cazares Méndez M, López-Ugalde M. Perinatal factors associated with the development of cow's milk protein allergy. Rev Gastroenterol Mex. 2015 Jan-Mar; 80(1):27-31.
  3. C. Cohet, S. Cheng, C. MacDonald, M. Baker, S. Foliaki, N. Huntington, et al.

Infections, medication use, and the prevalence of symptoms of asthma, rhinitis, and eczema in childhood.J Epidemiol Community Health, 58 (2004), pp. 852-857

  1. T.M. McKeever, S.A. Lewis, C. Smith, J. Collins, H. Heatlie, M. Frischer, et al.Early exposure to infections and antibiotics and the incidence of allergic disease: a birth cohort study with the West Midlands General Practice Research Database.J Allergy Clin Immunol, 109 (2002), pp. 43-50
  2. M. Wjst, B. Hoelscher, C. Frye, H.E. Wichmann, S. Dold, J. Heinrich Early antibiotic treatment and later asthma.Eur J Med Res, 6 (2001), pp. 263-271
  3. Thomas M, Custovic A, Woodcock A, Morris J, Simpson A, Murray CS. Atopic wheezing and early life antibiotic exposure: a nested case-control study. Pediatr Allergy Immunol. 2006 May; 17(3):184-8.
  4. Mullooly JP, Schuler R, Barrett M, Maher JE. Vaccines, antibiotics, and atopy. Pharmacoepidemiol Drug Saf. 2007 Mar; 16(3):275-88.
  5. Foliaki S, Pearce N, Björkstén B, Mallol J, Montefort S, von Mutius E; International Study of Asthma and Allergies in Childhood Phase III Study Group. Antibiotic use in infancy and symptoms of asthma, rhinoconjunctivitis, and eczema in children 6 and 7 years old: International Study of Asthma and Allergies in Childhood Phase III. J Allergy Clin Immunol. 2009 Nov; 124(5):982-9
  6. K.R. Risnes, K. Belanger, W. Murk, M.B. Bracken.Antibiotic exposure by 6 months and asthma and allergy at 6 years: findings in a cohort of 1,401 US children.Am J Epidemiol, 173 (2011), pp. 310-318
  7. Kozyrskyj AL, Ernst P, Becker AB. Increased risk of childhood asthma from antibiotic use in early life. Chest. 2007 Jun; 131(6):1753-9.
  8. Garcia-Marcos L, González-Díaz C, Garvajal-Urueña I, Pac-Sa MR, Busquets-Monge RM, Suárez-Varela MM, Batlles-Garrido J, Blanco-Quirós A, Varela AL, García-Hernández G, Aguinaga-Ontoso I. Early exposure to paracetamol or to antibiotics and eczema at school age: modification by asthma and rhinoconjunctivitis. Pediatr Allergy Immunol. 2010 Nov; 21(7):1036-42.
  9. Verhulst SL, Vael C, Beunckens C, Nelen V, Goossens H, Desager K. A longitudinal analysis on the association between antibiotic use, intestinal microflora, and wheezing during the first year of life. J Asthma. 2008 Nov; 45(9):828-32
  10. Johnson CC, Ownby DR, Alford SH, Havstad SL, Williams LK, Zoratti EM, Peterson EL, Joseph CL. Antibiotic exposure in early infancy and risk for childhood atopy. J Allergy Clin Immunol. 2005 Jun; 115(6):1218-24.
  11. Mai XM, Kull I, Wickman M, Bergström A. Antibiotic use in early life and development of allergic diseases: respiratory infection as the explanation. Clin Exp Allergy. 2010 Aug; 40(8):1230-7.
  12. Wickens K, Ingham T, Epton M, Pattemore P, Town I, Fishwick D, Crane J; New Zealand Asthma and Allergy Cohort Study Group. The association of early life exposure to antibiotics and the development of asthma, eczema and atopy in a birth cohort: confounding or causality? Clin Exp Allergy. 2008 Aug; 38(8):1318-24
  13. Kusel MM, de Klerk N, Holt PG, Sly PD. Antibiotic use in the first year of life and risk of atopic disease in early childhood. Clin Exp Allergy. 2008 Dec; 38(12):1921-8.
  14. Celedón JC, Litonjua AA, Ryan L, Weiss ST, Gold DR. Lack of association between antibiotic uses in the first year of life and asthma, allergic rhinitis, or eczema at age 5 years. Am J Respir Crit Care Med. 2002 Jul 1; 166(1):72-5.
  15. J.C. Celedon, A. Fuhlbrigge, S. Rifas-Shiman, S.T. Weiss, J.A. Finkelstein
  16. Su Y, Rothers J, Stern DA, Halonen M, Wright AL. Relation of early antibiotic use to childhood asthma: confounding by indication? Clin Exp Allergy. 2010 Aug; 40(8):1222-9.
  17. Guarner F, Malagelada JR. Gut flora in health and disease. Lancet 2003; 361:512-9.
  18. Koletzko S, Niggemann B, Arato A, Dias JA, Heuschkel R, Husby S, Mearin ML, Papadopoulou A, Ruemmele FM, Staiano A, Schäppi MG, Vandenplas Y; European Society of Pediatric Gastroenterology, Hepatology, and Nutrition. Diagnostic approach and management of cow's-milk protein allergy in infants and children: ESPGHAN GI Committee practical guidelines. J Pediatr Gastroenterol Nutr. 2012 Aug; 55(2):221-9
Journal of Pediatric Perspectives
Volume 10, Issue 2
February 2022
Pages 15511-15520
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