Background Pathogens stimulate presepsin (P-SEP) shedding from immune cells such as macrophages, monocytes, and neutrophils. Although its function is still unclear, P-SEP is believed to interact with B and T cells to modulate specific immune responses. We aimed to evaluate the accuracy of P-SEP as a novel biomarker for the diagnosis of bacterial infection and correlate its level with blood culture, C-reactive protein (CRP), and procalcitonin (PCT) levels. Materials and Methods: This is a prospective comparative study conducted at Minia University Hospital, Egypt, including eighty neonates. They were divided into two groups: Group I: Twenty full term neonates; infants > 37 weeks. Group II: Sixty preterm neonates Group II A: 20 Low birth weight neonates: 1501- 2500 gr, Group IIB: 20 Very low birth weight neonates: 1001-1500 gr, Group II C: 20 Extremely low birth weight neonates: 500-1000 gr. Cord presepsin (presepsin 1) was measured at birth. CBC, CRP, Blood culture, Procalcitonin and presepsin 2 were measured after the onset of sepsis. Results: No significant difference in levels of P-SEP 1 was found between the two groups.P-SEP 2 levels were higher in sepsis group than in non-sepsis group. Presepsin showed more diagnostic accuracy than PCT in diagnosis of sepsis. The best cut-off value for Presepsin was 485 pg/ml, with 97.8% sensitivity, and 94.1% specificity. Conclusion Presepsin as a biomarker is not only suitable for early diagnosis of sepsis but it is also more accurate than both PCT and CRP.
Kamel, M. M. , Abd-ullah, H. F. , El Sayed, M. A. and Abdel Aziz, R. A. (2021). Presepsin as an Early Predictor of Neonatal Sepsis. Journal of Pediatric Perspectives, 9(4), 13359-13369. doi: 10.22038/ijp.2021.55127.4345
MLA
Kamel, M. M. , , Abd-ullah, H. F. , , El Sayed, M. A. , and Abdel Aziz, R. A.. "Presepsin as an Early Predictor of Neonatal Sepsis", Journal of Pediatric Perspectives, 9, 4, 2021, 13359-13369. doi: 10.22038/ijp.2021.55127.4345
HARVARD
Kamel, M. M., Abd-ullah, H. F., El Sayed, M. A., Abdel Aziz, R. A. (2021). 'Presepsin as an Early Predictor of Neonatal Sepsis', Journal of Pediatric Perspectives, 9(4), pp. 13359-13369. doi: 10.22038/ijp.2021.55127.4345
CHICAGO
M. M. Kamel , H. F. Abd-ullah , M. A. El Sayed and R. A. Abdel Aziz, "Presepsin as an Early Predictor of Neonatal Sepsis," Journal of Pediatric Perspectives, 9 4 (2021): 13359-13369, doi: 10.22038/ijp.2021.55127.4345
VANCOUVER
Kamel, M. M., Abd-ullah, H. F., El Sayed, M. A., Abdel Aziz, R. A. Presepsin as an Early Predictor of Neonatal Sepsis. Journal of Pediatric Perspectives, 2021; 9(4): 13359-13369. doi: 10.22038/ijp.2021.55127.4345