Authors
1 Associate Professor of Pediatric, Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
2 Children and Adolescent Health Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran.
3 Resident of Pediatric, Department of Pediatrics, School of Medicine, Ali-Ibn-Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran.
Abstract
Background
In iron deficiency anemia (IDA), several changes in platelets indices have been reported in a number of studies. The aim of this study was to evaluate the platelet parameters in children with iron deficiency anemia before and after treatment.
Materials and Methods: This cross-sectional study was conducted over a period of 18 months. A total of 110 IDA subjects were selected from those who referred to the pediatric hematology clinic, Zahedan, Iran, during the study period. Age range was 12 months to 16 years were selected.Children in the study were given a 3 month course of oral iron as ferrous sulfate with a daily dose of 4mg/kg/day in 2 divided doses. Platelet parameters including platelet count and mean platelet volume (MPV) were measured before and after treatment. The obtained data were analyzed using SPSS software version 20.0.
Results: The mean age of the boys and girls was 4.30±4.55 years and 2.46±3.21 years, respectively. The results of the paired t- test showed that platelet means were 409±120 103 /mm3 and 384±99 103 /mm3 before and after treatment (p<0.001), respectively. The means of MPV increased from 8.07±1.01 fL before treatment to 8.86±1.05 fL after treatment (p<0.001), respectively.
Conclusion
The result of this study showed that treatment of iron deficiency anemia leads to decreased platelet count and increased MPV.
Keywords
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