Usefulness of Serum NT-proBNP in Diagnosis of Generalized Seizures in Egyptian Children

Mahgoob, Mohamed; Moussa, Mahmoud

doi:10.22038/ijp.2020.47471.3850

Authors

Mohamed Mahgoob ¹
Mahmoud Moussa ²

¹ Lecturer of Pediatrics, Pediatric Department, Faculty of Medicine, Minia University, Egypt. Address: Mina University, Faculty of Medicine, Minia, Egypt.

² Lecturer of Clinical Pathology, Department of Clinical Pathology, Faculty of Medicine, Minia University, Egypt.

https://doi.org/10.22038/ijp.2020.47471.3850

Abstract

Background
Seizures may occur in as many as 1% of children. The most urgent type of seizures is generalized tonic-clonic seizures (GTCS). N-terminal prohormone of brain natriuretic peptide (NT‐proBNP) has been considered as a promising biomarker in numerous acute illnesses. We aimed to evaluate usefulness of NT‐proBNP for diagnosis of generalized seizures in children.
Materials and Methods
This prospective case control study was conducted upon 80 children who were classified into four groups; Group I: included 20 patients with idiopathic generalized epileptic seizures. Group II: included 20 patients with focal epileptic seizures. Group III: included 20 patients with febrile seizures. Group IV: included 20 apparently healthy, age and sex matched children as a normal control. Complete blood count (CBC), blood chemistries, including random blood glucose, calcium, sodium, C-reactive protein (CRP) level, serum prolactin and NT‐proBNP were performed for all children.
Results
Our results revealed significant increase of both prolactin and NT‐proBNP in generalized epileptic and febrile seizure groups than in focal epileptic and control groups (p< 001). The ROC curve analysis showed NT‐proBNP, at a cut-off value of > 384 pg/ml, sensitivity (90 %), and specificity (70.2%) which was near the results of prolactin at a cut-off value> 25.9 ng/ml, and showed sensitivity (95.1%), and specificity (71.3%).
Conclusion
Based on the results, NT‐proBNP increase in generalized seizures either epileptic or febrile; and may be a promising marker to adjust the diagnosis of it at the emergency setting, when history and clinical presentation are equivocal.

Keywords

References

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Journal of Pediatric Perspectives

Usefulness of Serum NT-proBNP in Diagnosis of Generalized Seizures in Egyptian Children

References

References

Volume 8, Issue 4 - Serial Number 76
April 2020
Pages 11187-11195

Usefulness of Serum NT-proBNP in Diagnosis of Generalized Seizures in Egyptian Children

References

References

Volume 8, Issue 4 - Serial Number 76April 2020Pages 11187-11195

Volume 8, Issue 4 - Serial Number 76
April 2020
Pages 11187-11195