Comparison of Elevated Liver Enzymes in Type 2 Diabetic Patients in User and Non-User of Statin

Rajabian, Majid; Hussein Nejad, Elham; Taghizade Moghaddam, Habibolah

doi:10.22038/ijp.2018.34136.3015

Comparison of Elevated Liver Enzymes in Type 2 Diabetic Patients in User and Non-User of Statin

Authors

Majid Rajabian ¹

Elham Hussein Nejad ²

Habibolah Taghizade Moghaddam ³

¹ Faculty Member of Payame Noor University, Tehran, Iran.

² Master of Biochemistry, Payame Noor University, Mashhad, Iran.

³ Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

10.22038/ijp.2018.34136.3015

Abstract

Background: Type-2 diabetes is a risk factor for progressive non-alcoholic fatty liver disease and the majority of diabetic patients have blood lipid disorders, so they take statin drugs. Statins have the adverse effects such as liver dysfunction and increase in liver enzymes. The purpose of this study was to compare the liver enzymes in type 2 diabetic patients who are user and non-user of statin.
Methods:
In a case-control study, increased liver enzymes (ALT and AST > 40 U/L) were measured in blood samples of 200 type II diabetic patients (with and without statin consumption) who referred to Mashhad Diabetes Clinic in Mashhad city (Iran), during May to November 2017. Levels of liver enzymes and anthropometric indices were measured for both groups. Liver enzymes were assessed at the baseline of two groups. The SPSS 20th software was used for data analysis.
Results:
The mean of Body mass index in two groups of diabetic patients with and without statin consumption had a significant difference (p

Keywords

ALT

AST

Diabetes Mellitus

Statins