<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Journal of Pediatric Perspectives</title>
			<title_fa></title_fa>
			<short_title>JPP; J Ped Perspect</short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://jpp.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn></journal_id_issn>
			<journal_id_issn_online>3060-7205</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>2026</year>
				<month>8</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2026</year>
				<month>8</month>
				<day>1</day>
			</pubdate>
			<volume>14</volume>
			<number>8</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Relationship between Insulin Dosage and Metabolic Control (HbA1c) in Children and Adolescents with Type 1 Diabetes Mellitus</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>original article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Background: Insulin requirements in pediatric type 1 diabetes mellitus (T1DM) vary according to age, pubertal status, and metabolic factors; however, the relationship between insulin dose and glycemic control remains complex.Objective: This study aimed to evaluate the association between total daily insulin dose and metabolic control in children and adolescents with T1DM.Methods: In this cross-sectional study, 471 children and adolescents with T1DM attending an endocrine clinic were evaluated. HbA1c was measured on two separate occasions at a three-month interval. Insulin dose was recorded at each monthly visit over the three-month observation period. Associations between total daily insulin dose (U/kg/day), HbA1c, body mass index (BMI), diabetes duration, and pubertal stage were analyzed.Results: The mean age was 12.37 ± 3.95 years (range, 2.25–17.8 years), and the mean duration of diabetes was 4.69 ± 3.36 years. A significant positive correlation was observed between total daily insulin dose and HbA1c (r = 0.18, p &lt; 0.001). Insulin requirements increased significantly across pubertal stages (p &lt; 0.001). BMI showed a positive correlation with insulin dose among male participants (r = 0.20, p = 0.008). In multivariable regression analysis, total insulin dose was significantly associated with HbA1c (β = 0.74, 95% CI: 0.22–1.26, p = 0.006), whereas age, sex, diabetes duration, and pubertal stage were not significant predictors.Conclusion: Higher insulin doses were associated with poorer glycemic control, likely reflecting compensatory dose escalation rather than improved metabolic regulation. Pubertal status and BMI significantly influenced insulin requirements in children and adolescents with T1DM.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Body mass index, Insulin, Glycated hemoglobin, puberty, Microalbuminuria, Type 1 Diabetes Mellitus</keyword>
				<start_page>20292</start_page>
				<end_page>20301</end_page>
				<web_url>https://jpp.mums.ac.ir/article_28367.html</web_url>
			<author_list><author>
				<first_name>Victoria</first_name>
				<middle_name></middle_name>
				<last_name>Chegini</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>victoria_che@yahoo.com</email>
				<code>124642</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pediatric Critical Care Medicine, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sonia</first_name>
				<middle_name></middle_name>
				<last_name>Oveisi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>soniaoveisi@gmail.com</email>
				<code>124643</code>
				<coreauthor>No</coreauthor>
				<affiliation>Clinical Research Development Unit of Advanced Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Fatemeh</first_name>
				<middle_name></middle_name>
				<last_name>Saffari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>drfa_saffari@yahoo.com</email>
				<code>124644</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Non-communicable Diseases Research Center, Research Institute for Prevention of Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Does Type 1 Diabetes Affect Pulmonary Function in Children?</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>original article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Background: Diabetes mellitus type 1 (DM1) is a chronic autoimmune disease associated with micro- and macrovascular complications that may affect multiple organs, especially the kidneys and eyes. Its impact on the pulmonary system and pulmonary function is not clearly studied but is receiving attention in recent studies. In this study, we aimed to investigate the impact of DM1 on pulmonary function among children and young adolescents. Methods: In this cross-sectional study, children and adolescents with type 1 diabetes mellitus underwent pulmonary function testing (PFT). Respiratory function parameters were compared in well-controlled vs. poorly controlled diabetic children.Results: Our findings showed that pulmonary function in DM1 patients was generally within normal ranges, with no significant differences based on A1C levels, Diabetic ketoacidosis (DKA) frequency, or diabetes duration. A direct relationship was detected between weight Z-scores and both forced expiratory volume in one second (FEV₁) and forced vital capacity (FVC) indices; however, this association was not statistically significant. Conclusion: Normal FEV1 and FVC levels indicate that DM1 does not significantly impair pulmonary function. Further studies with larger sample sizes and longitudinal investigations are suggested. So, we cannot suggest pulmonary function testing as a routine screening test for diabetic children.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Child, Diabetic Ketoacidosis, Diabetes Mellitus, Pulmonary function tests, Type 1</keyword>
				<start_page>20302</start_page>
				<end_page>20308</end_page>
				<web_url>https://jpp.mums.ac.ir/article_28425.html</web_url>
			<author_list><author>
				<first_name>Nasrin</first_name>
				<middle_name></middle_name>
				<last_name>Moazzen</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>moazzenn@mums.ac.ir</email>
				<code>124874</code>
				<coreauthor>No</coreauthor>
				<affiliation>Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mohammad</first_name>
				<middle_name></middle_name>
				<last_name>Pordel Barabadi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>pordelm@yahoo.com</email>
				<code>124875</code>
				<coreauthor>No</coreauthor>
				<affiliation>Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Nafiseh</first_name>
				<middle_name></middle_name>
				<last_name>Todarbari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>todarbarin@mums.ac.ir</email>
				<code>124876</code>
				<coreauthor>No</coreauthor>
				<affiliation>Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sara</first_name>
				<middle_name></middle_name>
				<last_name>Ghahramani</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ghahremanis@mims.ac.ir</email>
				<code>124877</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Tahereh</first_name>
				<middle_name></middle_name>
				<last_name>Sadeghi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sadeghit@mums.ac.ir</email>
				<code>124878</code>
				<coreauthor>No</coreauthor>
				<affiliation>Nursing and Midwifery Care Research Center, Akbar Children Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Sepideh</first_name>
				<middle_name></middle_name>
				<last_name>Bagheri</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>bagheris@mums.ac.ir</email>
				<code>124879</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Pediatric Endocrinology and Metabolism, Faculty of Medicine, Mashhad    University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Prevalence of Pneumonia in Children with Acute Leukemia in the Oncology Wards of Teaching Hospitals in Urmia, Iran: A Retrospective Cross-Sectional Study</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>original article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Background: Pneumonia is a major cause of morbidity and mortality in children with acute lymphoblastic leukemia (ALL). However, detailed regional epidemiological data are scarce. This study aimed to determine the prevalence and characterize the clinical profile of pneumonia among pediatric ALL patients in Urmia, Iran.Methods: A retrospective cross-sectional study was conducted on children (≤18 years) with ALL admitted to oncology wards of teaching hospitals in Urmia from 2020 to 2023. Pneumonia was defined using modified Centers for Disease Control and Prevention (CDC) criteria. Data on demographics, clinical characteristics, microbiology, and outcomes were extracted from medical records. Period prevalence, incidence density, and risk factors were analyzed using appropriate statistical tests. Nutritional status was assessed using body mass index (BMI) z-scores, with underweight defined as a BMI z-score &lt; -2 standard deviations.Results: Of 150 eligible patients, 62 (41.3%) developed at least one episode of pneumonia, yielding a period prevalence of 41.3% (95% CI: 33.5–49.1%). Ninety-eight pneumonia episodes were identified, with an incidence density of 5.23 per 1000 patient-days. Most episodes (67.3%) were clinically diagnosed. Microbiological confirmation (32.7% of episodes) identified bacterial (62.5%), viral (25.0%), and fungal (12.5%) pathogens, with Pseudomonas aeruginosa being most common. Severe neutropenia (ANC &lt;500 cells/µL) (adjusted OR: 4.2, 95% CI: 2.1–8.4; p&lt;0.001) and high-risk ALL (adjusted OR: 2.8, 95% CI: 1.3–6.0; p=0.009) were independent risk factors. Underweight status was associated with increased pneumonia risk in univariate analysis (OR: 2.1, 95% CI: 1.1–4.0; p=0.03) but was not an independent predictor in multivariable analysis. Complications included intensive care unit (ICU) admission (22.4%) and pneumonia-associated mortality (6.1%).Conclusions: Pneumonia is highly prevalent and severe in pediatric ALL patients in this setting, strongly associated with severe neutropenia and high-risk disease. Findings underscore the need for enhanced surveillance, optimized prophylaxis, and prompt management to mitigate this major infectious complication.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>acute lymphoblastic leukemia, Child, Pneumonia, Prevalence</keyword>
				<start_page>20309</start_page>
				<end_page>20322</end_page>
				<web_url>https://jpp.mums.ac.ir/article_28262.html</web_url>
			<author_list><author>
				<first_name>Yousef</first_name>
				<middle_name></middle_name>
				<last_name>Mohammadpour</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mohammadpour.yousef@gmail.com</email>
				<code>124262</code>
				<coreauthor>No</coreauthor>
				<affiliation>Patient Safety Research Center, Clinical Research Institute, Nursing &amp; Midwifery School, Urmia University of Medical Sciences, Urmia, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Reza</first_name>
				<middle_name></middle_name>
				<last_name>Abdollahi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>rezaabdollahi97@yahoo.com</email>
				<code>124263</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Patient Safety Research Center, Clinical Research Institute, Nursing &amp; Midwifery School, Urmia University of Medical Sciences, Urmia, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Topical Sheep Oil and Pain Intensity and Crying Duration Following Pentavalent Vaccination in Two-Month-Old Infants: A Quasi-Experimental Study</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>original article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Background: Vaccination is essential for preventing infectious diseases, but injection-related pain is a common painful experience in infancy. This study evaluated the association of topical sheep oil with pain intensity and crying duration during pentavalent vaccination in two-month-old infants.Methods: In this quasi-experimental study, 72 healthy two-month-old infants were recruited via convenience sampling and nonrandomly assigned to intervention (n = 36) and control (n = 36) groups. Purified sheep oil (2.5 mL) was applied over the vastus lateralis muscle 60 minutes before vaccination. Pain was assessed using the Modified Behavioral Pain Scale before, during, and after vaccination, and crying duration was measured using a digital stopwatch.Results:  Baseline characteristics were comparable between groups (all P &gt; 0.05). Pain scores were lower in the sheep oil group during vaccination (P = 0.024) and 15 seconds after vaccination (P &lt; 0.001), with a significant time × group interaction (P &lt; 0.001). Crying duration was 15 (13–17) seconds in the intervention group versus 18.5 (15–20) seconds in the control group (P = 0.050).Conclusion: Topical sheep oil was associated with lower pain intensity and shorter crying duration after pentavalent vaccination. Given the non-randomized design, randomized controlled trials are needed to confirm these findings.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Complementary Medicine, Infant, Pentavalent Vaccine, Procedural pain, Sheep oil, Vaccine Methods</keyword>
				<start_page>20323</start_page>
				<end_page>20334</end_page>
				<web_url>https://jpp.mums.ac.ir/article_28431.html</web_url>
			<author_list><author>
				<first_name>Zahra</first_name>
				<middle_name></middle_name>
				<last_name>AmirPour Said</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>zahrasadat.amirpoorsaid74@yahoo.com</email>
				<code>124905</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Nursing, Faculty of Nursing, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Fatemeh</first_name>
				<middle_name></middle_name>
				<last_name>Hosseini</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>fati1317@gmail.com</email>
				<code>124906</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Community Health Nursing, School of Nursing and Midwifery, Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ali</first_name>
				<middle_name></middle_name>
				<last_name>Akbari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>iccn89@gmail.com</email>
				<code>124907</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Medical Surgical Nursing, School of Nursing and Midwifery,  Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Seyed Hamid</first_name>
				<middle_name></middle_name>
				<last_name>Seyed Bagheri</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hamidsiba@gmail.com</email>
				<code>124908</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pediatric Nursing, Nursing and Midwifery School, Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Parvin</first_name>
				<middle_name></middle_name>
				<last_name>Khalili</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hossini1389@yahoo.com</email>
				<code>124909</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Epidemiology, Faculty of Public Health, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Nano-curcumin for Clinical Symptoms and Gastrointestinal Inflammation in Children with Celiac Disease: A Pilot Randomized Controlled Trial Protocol</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>original article</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Background: Celiac disease (CD) is a chronic, systemic immune-mediated condition triggered by gluten exposure in genetically predisposed individuals and characterized by intestinal inflammation, mucosal injury, and impaired nutrient absorption. Lifelong adherence to a strict gluten-free diet remains the cornerstone of treatment, yet inflammatory and gastrointestinal manifestations may persist despite dietary adherence. Curcumin has anti-inflammatory and antioxidant properties and may modulate T-cell activation, antigen-presenting cell function, inflammatory signaling, oxidative stress, intestinal barrier integrity, and gut microbial balance. This pilot randomized controlled trial was designed to investigate whether adjunctive nano-curcumin can improve disease-related clinical manifestations and inflammatory biomarkers in children with CD.Methods: This prospective, single-center, double-blind, placebo-controlled, parallel-group pilot trial will be conducted at Akbar Children&#039;s Hospital, Mashhad, Iran. Thirty eligible children aged 5–18 years with celiac disease of less than six months&#039; duration will be randomly allocated in a 1:1 ratio to nano-curcumin (80 mg/day) or matched placebo for 12 weeks while receiving a gluten-free diet. The two primary outcomes are changes from baseline to week 12 in fecal calprotectin and serum tissue transglutaminase IgA (tTG-IgA). Secondary outcomes are gastrointestinal symptoms measured by the Gastrointestinal Symptom Rating Scale (GSRS) and standardized anthropometric measures. The primary analysis will use baseline-adjusted analysis of covariance (ANCOVA); logarithmic transformation will be considered for markedly right-skewed positive biomarker values. Because this is an exploratory pilot trial, the study is not powered to provide definitive evidence of efficacy.Conclusion: This pilot trial will evaluate the feasibility and preliminary effects of adjunctive nano-curcumin on gastrointestinal symptoms and inflammatory and serological outcomes in children with newly diagnosed CD receiving a gluten-free diet. The study is intended to generate preliminary estimates of treatment effects and outcome variability rather than establish definitive clinical efficacy. Its findings may provide an empirical basis for the design of a subsequent adequately powered randomized controlled trial.Trial registration: Iranian Registry of Clinical Trials IRCT20240721062501N1. Registered on October 19, 2024.]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Celiac disease, Curcumin, Inflammation, Immunomodulation, Pediatrics</keyword>
				<start_page>20335</start_page>
				<end_page>20352</end_page>
				<web_url>https://jpp.mums.ac.ir/article_28366.html</web_url>
			<author_list><author>
				<first_name>Seyed-Ali</first_name>
				<middle_name></middle_name>
				<last_name>Jafari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>jafaria@mums.ac.ir</email>
				<code>124636</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pediatric Gastroenterology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Ali</first_name>
				<middle_name></middle_name>
				<last_name>Molaei</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>a.mollaei.7@gmail.com</email>
				<code>124637</code>
				<coreauthor>No</coreauthor>
				<affiliation>Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Emad</first_name>
				<middle_name></middle_name>
				<last_name>Molaei</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>molaeik-e@razi.tums.ac.ir</email>
				<code>124638</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Clinical Pharmacy, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Saeedeh</first_name>
				<middle_name></middle_name>
				<last_name>Talebi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>talebis@mums.ac.ir</email>
				<code>124639</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mahsa</first_name>
				<middle_name></middle_name>
				<last_name>Mohammadzadeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>mahsazade800@gmail.com</email>
				<code>124635</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mahmood Reza</first_name>
				<middle_name></middle_name>
				<last_name>Jafari</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>jafarimr@mums.ac.ir</email>
				<code>124640</code>
				<coreauthor>No</coreauthor>
				<affiliation>Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Tahereh</first_name>
				<middle_name></middle_name>
				<last_name>Sadeghi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>sadeghit@mums.ac.ir</email>
				<code>124641</code>
				<coreauthor>No</coreauthor>
				<affiliation>Faculty of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Porphyria-like Neurological Crises and Fanconi Syndrome-Type Renal Tubular Disorder in An Undiagnosed Case of Chronic Tyrosinemia Type 1: A Case Report and Review of the Literature</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type>case report</content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Background: Tyrosinemia type 1 (TYRSN1) is an autosomal recessive metabolic disease that occurs due to a defect in the enzyme fumarylacetoacetate hydroxylase. In the case of a defect in this enzyme, toxic metabolites resulting from the breakdown of tyrosine accumulate in vital organs, leading to various symptoms and problems in these patients.Case Presentation: A 3-year-old boy was admitted to the hospital with confusion, constipation, vomiting, abdominal pain, fever, oliguria, and anorexia. On examination, hypertension, genu varum, abnormal gait, and urinary retention were observed. Laboratory tests revealed hypoglycemia, glucosuria, metabolic acidosis, anemia, hypokalemia, and hypocalcemia. Ultrasound and CT scans revealed large kidneys and a heterogeneous liver, with multiple nodules. Additional tests revealed elevated alkaline phosphatase, a high alpha-fetoprotein level, hypophosphatemia, and increased urinary excretion of phosphorus and potassium. Hand radiography also revealed rickets. Due to suspicion of hereditary diseases of amino acid metabolism, blood and urine chromatography revealed a marked accumulation of tyrosine. The diagnosis of chronic TYRSN1 was confirmed by measuring high urinary excretion of succinylacetone. The patient was treated with nitisinone and a restricted diet of tyrosine and phenylalanine, and within 1 week, he showed a dramatic response to treatment.Conclusion: Our patient was a case of chronic TYRSN1 who, owing to a lack of timely diagnosis, had symptoms of neurological crises similar to acute porphyria, as well as symptoms of Fanconi syndrome-type renal tubular disorder and rickets. Due to the rarity of this disease and its diverse clinical manifestations, its diagnosis is challenging in countries such as Iran, where screening for this disease is not routinely]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>Fumarylacetoacetate deficiency, Neurological crises, Tyrosinemia type 1</keyword>
				<start_page>20353</start_page>
				<end_page>20371</end_page>
				<web_url>https://jpp.mums.ac.ir/article_28432.html</web_url>
			<author_list><author>
				<first_name>Ehsan</first_name>
				<middle_name></middle_name>
				<last_name>Adib</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>ehsanadib2001@gmail.com</email>
				<code>124910</code>
				<coreauthor>No</coreauthor>
				<affiliation>Students Research Committee, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.|Cancer Immunology and Immunotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Nima</first_name>
				<middle_name></middle_name>
				<last_name>Abbasi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>n.abbasi@arums.ac.ir</email>
				<code>124911</code>
				<coreauthor>No</coreauthor>
				<affiliation>Students Research Committee, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Elina</first_name>
				<middle_name></middle_name>
				<last_name>Salehzadeh</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>salehzadehelina@yahoo.com</email>
				<code>124912</code>
				<coreauthor>No</coreauthor>
				<affiliation>Students Research Committee, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Nahideh</first_name>
				<middle_name></middle_name>
				<last_name>Ekhlasi</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>nahideh.ekhlasi80@gmail.com</email>
				<code>124913</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Pediatric Department of Bou Ali Hospital, Ardabil University of Medical Sciences, Ardabil, Iran.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>