<?xml version="1.0" encoding="utf-8"?>
			<journal>
			<title>Journal of Pediatric Perspectives</title>
			<title_fa></title_fa>
			<short_title>JPP; J Ped Perspect</short_title>
			<subject>Medical Sciences</subject>
			<web_url>https://jpp.mums.ac.ir/</web_url>
			<journal_hbi_system_id>0</journal_hbi_system_id>
			<journal_hbi_system_user></journal_hbi_system_user>
			<journal_id_issn></journal_id_issn>
			<journal_id_issn_online>3060-7205</journal_id_issn_online>
			<journal_id_pii></journal_id_pii>
			<journal_id_doi></journal_id_doi>
			<journal_id_iranmedex></journal_id_iranmedex>
			<journal_id_magiran></journal_id_magiran>
			<journal_id_sid></journal_id_sid>
			<journal_id_nlai></journal_id_nlai>
			<journal_id_science></journal_id_science>
			<language>en</language>
			<pubdate>
				<type>jalali</type>
				<year>0</year>
				<month>0</month>
				<day>1</day>
			</pubdate>
			<pubdate>
				<type>gregorian</type>
				<year>2021</year>
				<month>4</month>
				<day>1</day>
			</pubdate>
			<volume>9</volume>
			<number>4</number>
			<publish_type>online</publish_type>
			<publish_edition>1</publish_edition>
			<article_type>fulltext</article_type>
			<articleset><article>
				<language>en</language>
				<article_id_issn></article_id_issn>
				<article_id_issn_online></article_id_issn_online>
				<article_id_pubmed></article_id_pubmed>
				<article_id_pii></article_id_pii>
				<article_id_doi></article_id_doi>
				<article_id_iranmedex></article_id_iranmedex>
				<article_id_magiran></article_id_magiran>
				<article_id_sid></article_id_sid>
				<title_fa></title_fa>
				<title>Presepsin as an Early Predictor of Neonatal Sepsis</title>
				<subject_fa></subject_fa>
				<subject></subject>
				<content_type_fa></content_type_fa>
				<content_type></content_type>
				<abstract_fa><![CDATA[]]></abstract_fa>
				<abstract><![CDATA[Background Pathogens stimulate presepsin (P-SEP) shedding from immune cells such as macrophages, monocytes, and neutrophils.  Although its function is still unclear, P-SEP is believed to interact with B and T cells to modulate specific immune responses. We aimed to evaluate the accuracy of P-SEP as a novel biomarker for the diagnosis of bacterial infection and correlate its level with blood culture, C-reactive protein (CRP), and procalcitonin (PCT) levels. Materials and Methods: This is a prospective comparative study conducted at Minia University Hospital, Egypt, including eighty neonates. They were divided into two groups: Group I: Twenty full term neonates; infants &gt; 37 weeks. Group II: Sixty preterm neonates Group II A: 20 Low birth weight neonates: 1501- 2500 gr, Group IIB: 20 Very low birth weight neonates: 1001-1500 gr, Group II C: 20 Extremely low birth weight neonates: 500-1000 gr. Cord presepsin (presepsin 1) was measured at birth. CBC, CRP, Blood culture, Procalcitonin and presepsin 2 were measured after the onset of sepsis. Results: No significant difference in levels of P-SEP 1 was found between the two groups.P-SEP 2 levels were higher in sepsis group than in non-sepsis group. Presepsin showed more diagnostic accuracy than PCT in diagnosis of sepsis. The best cut-off value for Presepsin was 485 pg/ml, with 97.8% sensitivity, and 94.1% specificity. Conclusion Presepsin as a biomarker is not only suitable for early diagnosis of sepsis but it is also more accurate than both PCT and CRP.   ]]></abstract>
				<keyword_fa></keyword_fa>
				<keyword>prespsin, Procalcitonin, Sepsis, Neonates</keyword>
				<start_page>13359</start_page>
				<end_page>13369</end_page>
				<web_url>https://jpp.mums.ac.ir/article_17468.html</web_url>
			<author_list><author>
				<first_name>Magdy Mostafa</first_name>
				<middle_name></middle_name>
				<last_name>Kamel</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email></email>
				<code>74864</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pediatrics, Faculty of Medicine, Minia University, Egypt.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Hossam Fathey</first_name>
				<middle_name></middle_name>
				<last_name>Abd-ullah</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>hossamfathey6@gmail.com</email>
				<code>74862</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Pediatrics, Faculty of Medicine, Minia University, Egypt.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Mostafa Ahmed</first_name>
				<middle_name></middle_name>
				<last_name>El Sayed</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>elmostafa_lab@yahoo.com</email>
				<code>74863</code>
				<coreauthor>No</coreauthor>
				<affiliation>Department of Clinical Pathology, Faculty of Medicine, Minia University, Egypt.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author><author>
				<first_name>Reem</first_name>
				<middle_name>A.</middle_name>
				<last_name>Abdel Aziz</last_name>
				<suffix></suffix>
				<first_name_fa></first_name_fa>
				<middle_name_fa></middle_name_fa>
				<last_name_fa></last_name_fa>
				<suffix_fa></suffix_fa>
				<email>reemabdelsalam3@gmail.com</email>
				<code>74861</code>
				<coreauthor>Yes</coreauthor>
				<affiliation>Department of Pediatrics, Faculty of Medicine, Minia University, Egypt.</affiliation>
				<affiliation_fa></affiliation_fa>
				 </author></author_list>
				</article>
			</articleset>
			</journal>