Journal of Pediatric Perspectives

Investigating the Diagnostic Value of Interleukin 33 Biomarker in the Diagnosis of Biliary Atresia in Infants with Cholestasis Admitted to Akbar Hospital in Mashhad

Forogh Ali Akbarniya Omran; Mohammadali Kiani; Hamid Ahanchian; Seyed Ali Jafari; Maryam Khalesi; hamidreza kianifar; Sayyed Amir Hossein Ghazizadeh Hashemi

Volume 12, Issue 9 , September 2024, , Pages 19008-19021

https://doi.org/10.22038/jpp.2024.84856.5514

Abstract

Background: Neonatal cholestasis is one of the important liver diseases in children; and infants are more prone to it due to the immaturity of the liver. It appears due to several reasons ... Read More Background: Neonatal cholestasis is one of the important liver diseases in children; and infants are more prone to it due to the immaturity of the liver. It appears due to several reasons and its treatment is determined based on its cause. If the cause is not diagnosed in time and rapid treatment is not adopted, it will result in irreparable complications. Biliary atresia is the main cause of this disease and the most common symptom of the need for liver transplantation in children, which requires early diagnosis as a prognostic factor of the disease and its immediate differentiation from other causes of cholestasis. Considering the use of new diagnostic biomarkers, the present study was conducted with the aim of investigating the diagnostic value of serum interleukin 33 (IL-33) in infants with cholestasis and its relationship with clinical and laboratory data.Methods: This research is a cross-sectional study, conducted on infants referred to the gastroenterology clinic of Akbar Hospital in Mashhad during the years 2021 and 2022. According to the entry and exit criteria, cholestatic infants were included in the study in two groups with and without biliary atresia along with the control group (healthy infants). The basic information, clinical manifestations, and laboratory findings of infants were collected through a researcher-made checklist; and recorded in SPSS software version 24. Data description and analyses were done using descriptive indices, statistical tests, regression methods, and rock curve at a significance level of less than 0.05.Results: The participants included 78 infants with an average age of 2.80 ± 1.42 months, enrolled in three groups (26 cases each). The intervention groups consisted of patients with cholestasis with and without biliary atresia; and there was one group of healthy infants as the control group. The serum level of IL-33 biomarker was significantly higher in patients with biliary atresia than in patients without atresia (p=0.014); and in both groups, it was higher than that in the control group (p=0.001). The serum level of IL-33 had a significant positive correlation with laboratory indicators of AST, ALT and GGT (p<0.05). Interleukin-33 serum level at the cut-off point of 275 pg/ml can diagnose biliary atresia with a sensitivity of 84.6 and a specificity of 92.3%, so that the probability of biliary atresia in infants with IL-33 ≥ 275 is reported to be twice as often higher than that in infants with A serum levels lower than this value (p=0.011).Conclusion: The serum level of interleukin 33 was significantly higher in patients with biliary atresia than in patients without atresia as well as in healthy infants; and at the determined cut-off point, it had a favorable diagnostic value for identifying infants with biliary atresia.

The Diagnostic Value of Different Sonography Findings and Color Doppler Sonography in Detecting Biliary Atresia in Infants and Neonates

Mohammad Ali Kiani; Seyed Ali Jafari; Homa Jajarmi Khayyat; Seyed Ali Alamdaran; Masood Mahdavi Rashed; Maryam Khalesi; Elham Bakhtiari

Volume 10, Issue 7 , July 2022, , Pages 16281-16290

https://doi.org/10.22038/ijp.2022.59436.4635

Abstract

Background: Biliary atresia (BA) is one of the most common etiologies of cholestasis in infants and toddlers. The most important factor in case of patients’ prognosis is its early ... Read More

Non-Invasive Diagnostic Methods for Differentiation of Biliary Atresia from Neonatal Hepatitis in Upper Egypt

Ashraf Abou-Taleb; Wafaa Abdelhameed; Ahmed Ahmed; Ahmed El-Hennawy

Volume 7, Issue 4 , April 2019, , Pages 9265-9275

https://doi.org/10.22038/ijp.2018.36960.3219

Abstract

Background Cholestatic jaundice in infancy is always pathologic and mainly caused by biliary atresia (BA), and neonatal hepatitis (NH). The early discrimination of both conditions is ... Read More

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Keywords = Biliary atresia

Investigating the Diagnostic Value of Interleukin 33 Biomarker in the Diagnosis of Biliary Atresia in Infants with Cholestasis Admitted to Akbar Hospital in Mashhad

Abstract

The Diagnostic Value of Different Sonography Findings and Color Doppler Sonography in Detecting Biliary Atresia in Infants and Neonates

Abstract

Non-Invasive Diagnostic Methods for Differentiation of Biliary Atresia from Neonatal Hepatitis in Upper Egypt

Abstract