Journal of Pediatric Perspectives

Assessing the Correlation between Acid-Base Parameters, BUN/Creatinine Ratio, and eGFR in Children Aged 2–18 Years Hospitalized with Diabetic Ketoacidosis: A Retrospective Study at Heshmatieh Hospital, Sabzevar (2016–2022)

Vahid Sheikhi; Mahboubeh Neamatshahi; Parisa Fouji; Aghil Miri; Aghil Keykhosravi

Volume 13, Issue 3 , March 2025, , Pages 19377-19382

https://doi.org/10.22038/jpp.2025.86846.5532

Abstract

Background: Diabetic Ketoacidosis (DKA) is a life-threatening complication of diabetes mellitus, particularly prevalent in pediatric populations. This study aims to explore the correlation ... Read More Background: Diabetic Ketoacidosis (DKA) is a life-threatening complication of diabetes mellitus, particularly prevalent in pediatric populations. This study aims to explore the correlation between blood gas parameters, serum blood urea nitrogen (BUN)/creatinine (Cr) ratio, and estimated glomerular filtration rate (eGFR) in pediatric patients aged 2 to 18 years hospitalized with DKA at Heshmatieh Hospital in Sabzevar between 2016 and 2022.Methods: In this retrospective study, 84 patients diagnosed with diabetic ketoacidosis (DKA) were included. Arterial blood gas analysis was performed to assess pH, bicarbonate (HCO₃⁻), and anion gap levels, which are key parameters for evaluating DKA severity and guiding clinical management. Renal function was evaluated using the blood urea nitrogen-to-creatinine ratio (BUN/Cr) and estimated glomerular filtration rate (eGFR), as dehydration and metabolic disturbances during DKA may acutely impair kidney function. These laboratory markers were analyzed to explore their utility in monitoring both metabolic and renal status throughout the treatment course.Results: This investigation evaluates the interplay between these parameters to identify potential biomarkers for assessing DKA severity and predicting clinical outcomes. Preliminary findings suggest that abnormal blood gas values, elevated BUN/Cr ratios, and reduced eGFR levels are associated with more severe DKA presentations and prolonged hospital stays. The integration of these biomarkers into clinical practice may enhance early risk stratification, optimize fluid and electrolyte management, and improve overall patient outcomes.Conclusions: These findings underscore the importance of a multidisciplinary approach in managing pediatric DKA, emphasizing the role of laboratory parameters in guiding timely and effective interventions. Further research is warranted to validate these correlations and establish standardized protocols for their application in clinical settings.

Prophylactic Administration of Aminophylline to Prevent Renal Dysfunction in Asphyxiated Neonates

Reza Saeidi; Somaye Fatahi; Morteza Yaghoobi; Gholamali Maamouri; Mahmoud Hajipour

Volume 10, Issue 4 , April 2022, , Pages 15772-15778

https://doi.org/10.22038/ijp.2022.62820.4797

Abstract

Background: Neonatal asphyxia is one of the most common neonatal problems. And kidney injuries are one of the most important complications of asphyxia in infants. Therefore, this study ... Read More

Diagnostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Detection of Pediatric Acute Kidney Injury; a Systematic Review and Meta-Analysis

Anahita Izadi; Mahmoud Yousefifard; Babak Nakhjavan-Shahraki; Masoud Baikpour; Jalaledin Mirzay Razaz; Mostafa Hosseini

Volume 4, Issue 11 , November 2016, , Pages 3875-3895

https://doi.org/10.22038/ijp.2016.7783

Abstract

Background: Two questions about diagnostic value of urinary neutrophil gelatin associated lipocalin (uNGAL) in detection of acute kidney injury (AKI) in children have remained unanswered; ... Read More

Etiology and Outcome of Chronic Kidney Disease in Iranian Children

Neamatollah Ataei; Mostafa Hosseini; Masoud Baikpour; Fatemeh Ataei; Hosein Bloori Jirandeh; Behnaz Bazargani; Mahmoud Yousefifard; Arash Abbasi

Volume 4, Issue 7 , July 2016, , Pages 2105-2112

https://doi.org/10.22038/ijp.2016.6977

Abstract

Background Considering the significant geographical and ethnical differences in pattern of incidence, etiology and outcome of chronic kidney disease (CKD), the present study aimed to ... Read More

Journal of Pediatric Perspectives

Articles in Press

Current Issue

Volume 13 (2025)

Volume 12 (2024)

Volume 11 (2023)

Volume 10 (2022)

Volume 9 (2021)

Volume 8 (2020)

Volume 7 (2019)

Volume 6 (2018)

Volume 5 (2017)

Volume 4 (2016)

Volume 3 (2015)

Volume 2 (2014)

Volume 1 (2013)

Keywords = acute kidney injury

Assessing the Correlation between Acid-Base Parameters, BUN/Creatinine Ratio, and eGFR in Children Aged 2–18 Years Hospitalized with Diabetic Ketoacidosis: A Retrospective Study at Heshmatieh Hospital, Sabzevar (2016–2022)

Abstract

Prophylactic Administration of Aminophylline to Prevent Renal Dysfunction in Asphyxiated Neonates

Abstract

Diagnostic Value of Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Detection of Pediatric Acute Kidney Injury; a Systematic Review and Meta-Analysis

Abstract

Etiology and Outcome of Chronic Kidney Disease in Iranian Children

Abstract