Volume 12 (2024)
Volume 11 (2023)
Volume 10 (2022)
Volume 9 (2021)
Volume 8 (2020)
Volume 7 (2019)
Volume 6 (2018)
Volume 5 (2017)
Volume 4 (2016)
Volume 3 (2015)
Volume 2 (2014)
Volume 1 (2013)
Author = Gian Maria Pacifici
Number of Articles: 15
Clinical Pharmacology of the Antimalarial Artemisinin-Based Combination and other Artemisinins in Children
Volume 6, Issue 7 , July 2018, , Pages 7901-7928
Abstract
In 2010, there were estimated 219 million cases of malaria resulting in 666,000 deaths and two-thirds were children. Children are more vulnerable than adults to malaria parasites. In ... Read More
Multidrug Resistance in Infants and Children
Volume 6, Issue 2 , February 2018, , Pages 7055-7080
Abstract
Bacterial infections may cause disease and death. Infants and children are often subject to bacterial infections. Antimicrobials kill bacteria protecting the infected patients andreducing ... Read More
Management of Typhoid Fever and Bacterial Meningitis by Chloramphenicol in Infants and Children
Volume 6, Issue 1 , January 2018, , Pages 6783-6808
Abstract
Chloramphenicol inhibits protein synthesis in bacteria and is usually bacteriostatic but is bactericidal against Haemophilus influenzae, Streptococcus pneumoniae, and Neisseria meningitis. ... Read More
Clinical Pharmacology of Cefotaxime in Neonates and Infants: Effects and Pharmacokinetics
Volume 5, Issue 11 , November 2017, , Pages 6111-6138
Abstract
Cefotaxime is a bactericidal "third generation" cephalosporin has a broad-spectrum activity against gram-positive microorganisms and exceptional activity against most gram-negative ... Read More
Clinical Pharmacology of Ciprofloxacin in Neonates: Effects and Pharmacokinetics
Volume 5, Issue 6 , June 2017, , Pages 5023-5041
Abstract
Ciprofloxacin is the most commonly used fluoroquinolone. Ciprofloxacin is prescribed for 1 in 44 Americans. Ciprofloxacin is a broad-spectrum bactericidal antibiotic, effective against ... Read More
Clinical Pharmacokinetics of Gentamicin in Neonates
Volume 5, Issue 3 , March 2017, , Pages 4575-4599
Abstract
Gentamicin is a bactericidal aminoglycoside antibiotic, it inhibits the protein synthesis. Gentamicin is active against the majority of aerobic gram-negative bacilli such as Pseudomonas, ... Read More
Clinical Pharmacokinetics of Amikacin in Neonates
Volume 5, Issue 2 , February 2017, , Pages 4407-4428
Abstract
Amikacin is a bactericidal aminoglycoside. Aminoglycosides inhibit bacterial protein synthesis. The antibacterial spectrum of amikacin is the broadest of aminoglycosides. Because of ... Read More
Clinical Pharmacology of Meropenem in Neonates: Effects and Pharmacokinetics
Volume 4, Issue 11 , November 2016, , Pages 3925-3939
Abstract
Meropenem, a carbapenem antibiotic, has a broad-spectrum activity and is active against Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influencae, ... Read More
Effects of Iron in Neonates and Young Infants: a Review
Volume 4, Issue 7 , July 2016, , Pages 2256-2271
Abstract
Iron is essential to erythrocyte oxygen transport and is a catalyst for oxidative metabolism in all cells. Iron is absorbed by the duodenum and requires an acidic environment for optimal ... Read More
Effects of Vitamin B12 in Neonates and Young Infants
Volume 4, Issue 6 , June 2016, , Pages 1867-1876
Abstract
Vitamin B12 (cobalamin) is an essential coenzyme for nucleic acid synthesis. Animal protein is the major dietary source of vitamin B12. Deficiency of vitamin B12 leads to megaloblastic ... Read More
Effects of Vitamin E in Neonates and Young Infants
Volume 4, Issue 5 , May 2016, , Pages 1745-1757
Abstract
Vitamin E (alpha-tocopherol) is a potent and natural antioxidant. Vitamin E is concentrated from soybean oil. The Committee on Fetus and Newborn of the Academy of the American of Pediatrics ... Read More
Effects of Vitamins K in Neonates and Young Infants
Volume 4, Issue 4 , April 2016, , Pages 1611-1624
Abstract
Vitamin K is required for the hepatic production of blood coagulation factors II, VII, IX and X. The term vitamin K refers to a variety of fat-soluble 2-methyl-1, 4-naphthoquinone derivatives. ... Read More
Clinical Pharmacology of Fluconazole in Neonates: Effects and Pharmacokinetics
Volume 4, Issue 3 , March 2016, , Pages 1475-1489
Abstract
Fluconazole is commonly used both to prevent and to treat invasive neonatal Candida albicans infection. This drug is a potent, selective, triazole inhibitor of the fungal enzymes involved ... Read More
Effects of Vitamin A in Neonates and Young Infants
Volume 4, Issue 2 , February 2016, , Pages 1339-1354
Abstract
Vitamin A is the generic name given to a group of fat-soluble compounds including retinol (the alcohol form), retinyl esters, retinaldehyde and retinol acid. Deficiency, first recognized ... Read More
Effects of Vitamin D in Neonates and Young Infants
Volume 4, Issue 1 , January 2016, , Pages 1273-1285