Journal of Pediatric Perspectives

Evaluation of the Effect of Rosuvastatin on Portal Hypertension and Variceal Bleeding in Children with Compensated Cirrhosis

Maryam Marefat; Mohammad Ali Kiani; Masoud Mahdavirashed; Monavar Afzalagaie; Saeed Mohammadi; Hamidreza Kianifar; Seyyed Ali Jafari; Maryam Khalesi

Volume 13, Issue 1 , January 2025, , Pages 19254-19264

https://doi.org/10.22038/jpp.2025.85036.5516

Abstract

Background: Portal hypertension, a complication of chronic liver disease in children, can lead to severe gastrointestinal bleeding and an increased need for hospitalization and endoscopic ... Read More Background: Portal hypertension, a complication of chronic liver disease in children, can lead to severe gastrointestinal bleeding and an increased need for hospitalization and endoscopic treatment, potentially resulting in death. Statins, known for their anti-inflammatory, antioxidant, and anti-fibrotic effects, are used in the treatment of many chronic diseases. This study aimed to investigate the effects of rosuvastatin on improving portal pressure and esophageal varices while reducing bleeding associated with these conditions in children with cirrhosis.Methods: This randomized clinical trial was conducted in children with compensated liver cirrhosis at Akbar Children's Hospital in Mashhad, Iran, between March 2023 and November 2024. Initially, endoscopy and Doppler ultrasound were performed on 32 patients aged 7–17 years. The control group received standard treatments for portal hypertension, while the intervention group received rosuvastatin tablets in addition to standard treatments. After a 6-month period, Doppler ultrasound and control endoscopy were repeated. All clinical, laboratory, sonographic, and endoscopic data were analyzed by a statistician, and the results were reported.Results: The study included 32 children with cirrhosis (16 in the control group and 16 in the intervention group). The number of cases showing a decrease in ultrasonographic parameters of portal hypertension (SA-RI and RRA-RI) was higher in the rosuvastatin group (p=0.14 and 0.37). The grades of esophageal varices decreased by 26.7% and 20% in the control and rosuvastatin groups, respectively (p=0.66). Esophageal variceal bleeding occurred in 13.3% of cases in the control group and in 25% of cases in the rosuvastatin group,with no statistically significant difference between the two groups (p=0.41).Conclusion: Over the 6-month follow-up period, rosuvastatin did not demonstrate a beneficial effect in reducing portal hypertension and variceal bleeding in children with compensated liver cirrhosis.

The Survey of the Environmental Health Status and Safety of Public and Non- Public Elementary Schools in Mashhad, Iran

Farzaneh Akhound Noghani; Asiyeh Moteallemi; Hoseein Alidadi; Monavar Afzalaghaee; Zohreh Rahnama Bargard

Volume 7, Issue 12 , December 2019, , Pages 10523-10532

https://doi.org/10.22038/ijp.2019.44801.3695

Abstract

Background: Providing health facilities and attention to the physical and mental health of students are very important and it can affect the amount of their learning. The purpose of ... Read More

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Author = Monavar Afzalagaie

Evaluation of the Effect of Rosuvastatin on Portal Hypertension and Variceal Bleeding in Children with Compensated Cirrhosis

Abstract

The Survey of the Environmental Health Status and Safety of Public and Non- Public Elementary Schools in Mashhad, Iran

Abstract